G1 Transcription Factors Are Differentially Regulated in Saccharomyces cerevisiae by the Swi6-Binding Protein Stb1

Michael Costanzo; Oliver Schub; Brenda Andrews

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G1 Transcription Factors Are Differentially Regulated in Saccharomyces cerevisiae by the Swi6-Binding Protein Stb1

机译：G1转录因子在酿酒酵母中受Swi6-结合蛋白Stb1的差异调节。

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Stage-specific transcriptional programs are an integral feature of cell cycle regulation. In the budding yeast Saccharomyces cerevisiae, over 120 genes are coordinately induced in late G₁ phase by two heterodimeric transcription factors called SBF and MBF. Activation of SBF and MBF is an upstream initiator of key cell cycle events, including budding and DNA replication. SBF and MBF regulation is complex and genetically redundant, and the precise mechanism of G₁ transcriptional activation is unclear. Assays using SBF- and MBF-specific reporter genes revealed that the STB1 gene specifically affected MBF-dependent transcription. STB1 encodes a known Swi6-binding protein, but an MBF-specific function had not been previously suspected. Consistent with a specific role in regulating MBF, a STB1 deletion strain requires SBF for viability and microarray studies show a decrease in MBF-regulated transcripts in a swi4Δ mutant following depletion of Stb1. Chromatin immunoprecipitation experiments confirm that Stb1 localizes to promoters of MBF-regulated genes. Our data indicate that, contrary to previous models, MBF and SBF have unique components and might be distinctly regulated.

机译：特定于阶段的转录程序是细胞周期调控的重要特征。在萌芽的酿酒酵母中，被称为SBF和MBF的两个异二聚体转录因子在G _{1 晚期相协调地诱导了120多个基因。 SBF和MBF的激活是关键细胞周期事件（包括出芽和DNA复制）的上游启动子。 SBF和MBF调控是复杂的和遗传上的冗余，并且G _{1 转录激活的确切机制尚不清楚。使用SBF和MBF特异性报告基因的分析表明， STB1 基因特异性影响MBF依赖性转录。 STB1 编码一种已知的Swi6结合蛋白，但是以前没有人怀疑过MBF特定的功能。与调节MBF的特定作用一致， STB1 缺失菌株需要SBF才能具有活力，并且微阵列研究表明， swi4 Δ突变体中，MBF调节的转录本在耗尽后会减少机顶盒1。染色质免疫沉淀实验证实Stb1定位于MBF调控基因的启动子。我们的数据表明，与以前的模型相反，MBF和SBF具有独特的组件，并且可能受到明确的监管。}} 展开▼

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《Molecular and Cellular Biology》 |2003年第14期|共14页

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Michael Costanzo; Oliver Schub; Brenda Andrews;
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中图分类细胞生物学;

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1. Regulation of Transcription at theSaccharomyces cerevisiae Start Transition by Stb1, a Swi6-Binding Protein [J] . Yuen Ho, Michael Costanzo, Lynda Moore, Molecular and Cellular Biology . 1999,第8期

机译：啤酒酵母的转录调控由Swi6结合蛋白Stb1开始过渡。

2. Global Regulatory Functions of Oaf1p and Pip2p (Oaf2p), Transcription Factors That Regulate Genes Encoding Peroxisomal Proteins in Saccharomyces cerevisiae [J] . Igor V. Karpichev, Gillian M. Small Molecular and Cellular Biology . 1998,第11期

机译：Oaf1p和Pip2p（Oaf2p），转录因子调节酿酒酵母中过氧化物酶体蛋白基因的转录因子的全球调节功能。

3. Transcription of genes encoding trans-acting factors required for rRNA maturation/ribosomal subunit assembly is coordinately regulated with ribosomal protein genes and involves Rap1 in Saccharomyces cerevisiae [J] . Miyoshi K, Shirai C, Mizuta K Nucleic Acids Research . 2003,第7期

机译：rRNA成熟/核糖体亚基组装所需的编码反式作用因子的基因的转录受核糖体蛋白基因的协调调节，并涉及酿酒酵母中的Rap1

4. Regulation of Protein Expression by Transcription Factors in Saccharomyces cerevisiae [C] . Gennifer E. Merrihew, Ying Sonia Ting, Michael J. MacCoss ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：酵母菌酿酒酵母转录因子调节

5. Identification of factors regulating transcription termination by RNA polymerase II in Saccharomyces cerevisiae. [D] . Nedea, Eduard. 2009

机译：鉴定酿酒酵母中RNA聚合酶II调控转录终止的因素。

6. G1 Transcription Factors Are Differentially Regulated in Saccharomyces cerevisiae by the Swi6-Binding Protein Stb1 [O] . Michael Costanzo, Oliver Schub, Brenda Andrews 2003

机译：G1转录因子在酿酒酵母中受Swi6-结合蛋白Stb1的差异调节。

7. G1 Transcription Factors Are Differentially Regulated in Saccharomyces cerevisiae by the Swi6-Binding Protein Stb1 [O] . Costanzo, Michael, Schub, Oliver, Andrews, Brenda 2003

机译：G1转录因子在酿酒酵母中受Swi6-结合蛋白Stb1的差异调节。

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3. Hybrid gene PGAL1-PrP-GFP FOR THE ANALYSIS OF FACTORS GOVERNING blocks the aggregation and stable protein PrP in the yeast Saccharomyces cerevisiae [P] . 外国专利： RU2009115814A . 2010-11-10

机译：用于控制因子分析的杂种基因PGAL1-PrP-GFP阻止了酿酒酵母中的聚集和稳定的蛋白PrP

4. E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins [P] . 外国专利： US4546082A . 1985-10-08

机译：大肠杆菌/酿酒酵母质粒克隆载体，包含用于分泌和加工杂合蛋白的α-因子基因

5. FUSION PROTEIN HAVING TRANSCRIPTION FACTOR TRANSACTIVATION-REGULATING DOMAIN AND PROTEIN TRANSDUCTION DOMAIN, AND TRANSCRIPTION FACTOR FUNCTION INHIBITOR COMPRISING THE SAME [P] . 外国专利： EP2607380B1 . 2018-10-10

机译：具有转录因子-转录调控域和蛋白质转化域的融合蛋白，以及包含该转录因子的转录因子功能抑制剂

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G1 Transcription Factors Are Differentially Regulated in Saccharomyces cerevisiae by the Swi6-Binding Protein Stb1

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