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首页> 外文期刊>Molecular and Cellular Biology >Nob1p Is Required for Cleavage of the 3′ End of 18S rRNA
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Nob1p Is Required for Cleavage of the 3′ End of 18S rRNA

机译：切割18S rRNA 3'末端需要Nob1p

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摘要

We report the characterization of a novel factor, Nob1p (Yor056c), which is essential for the synthesis of 40S ribosome subunits. Genetic depletion of Nob1p strongly inhibits the processing of the 20S pre-rRNA to the mature 18S rRNA, leading to the accumulation of high levels of the 20S pre-rRNA together with novel degradation intermediates. 20S processing occurs within a pre-40S particle after its export from the nucleus to the cytoplasm. Consistent with a direct role in this cleavage, Nob1p was shown to be associated with the pre-40S particle and to be present in both the nucleus and the cytoplasm. This suggests that Nob1p accompanies the pre-40S ribosomes during nuclear export. Pre-40S export is not, however, inhibited by depletion of Nob1p.
机译：我们报告表征的新型因子，Nob1p（Yor056c），这是合成40S核糖体亚基必不可少的。 Nob1p的遗传耗竭强烈抑制20S pre-rRNA向成熟的18S rRNA的加工，从而导致高水平的20S pre-rRNA与新型降解中间体的积累。从核输出到细胞质后，在20S之前的颗粒内进行20S处理。与这种切割的直接作用相一致，Nob1p被证明与40S之前的颗粒相关，并存在于细胞核和细胞质中。这表明Nob1p在核输出过程中伴随着40S之前的核糖体。但是，Nob1p的消耗不会抑制40S之前的出口。

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