DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

Xiaochun Yu; Junjie Chen

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DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

机译：DNA损伤诱导的细胞周期检查点控制需要CtIP，BRCA1 C末端域的磷酸化依赖性结合伙伴。

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The BRCA1 C-terminal (BRCT) domain has recently been implicated as a phospho-protein binding domain. We demonstrate here that a CTBP-interacting protein CtIP interacts with BRCA1 BRCT domains in a phosphorylation-dependent manner. The CtIP/BRCA1 complex only exists in G₂ phase and is required for DNA damage-induced Chk1 phosphorylation and the G₂/M transition checkpoint. However, the CtIP/BRCA1 complex is not required for the damage-induced G₂ accumulation checkpoint, which is controlled by a separate BRCA1/BACH1 complex. Taken together, these data not only implicate CtIP as a critical player in cell cycle checkpoint control but also provide molecular mechanisms by which BRCA1 controls multiple cell cycle transitions after DNA damage.

机译：BRCA1 C末端（BRCT）域最近被认为是磷酸蛋白结合域。我们在这里证明，CTBP相互作用蛋白CtIP与BRCA1 BRCT域以磷酸化依赖性方式相互作用。 CtIP / BRCA1复合物仅存在于G _{2 相中，是DNA损伤诱导的Chk1磷酸化和G _{2 / M转换检查点所必需的。但是，损伤诱导的G _{2 累积检查点不需要CtIP / BRCA1复合物，该检查点由单独的BRCA1 / BACH1复合物控制。综上所述，这些数据不仅暗示CtIP在细胞周期检查点控制中起着至关重要的作用，而且还提供了分子机制，使BRCA1在DNA损伤后控制多个细胞周期的转变。}}}

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《Molecular and Cellular Biology》 |2004年第21期|共9页
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Xiaochun Yu; Junjie Chen;
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中图分类细胞生物学;
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1. Expression of PCNA-binding domain of CtIP, a motif required for CtIP localization at DNA replication foci, causes DNA damage and activation of DNA damage checkpoint. [J] . Gu B, Chen PL Cell cycle . 2009,第9期

机译：CtIP的PCNA结合结构域（CtIP定位在DNA复制灶处所需的基序）的表达引起DNA损伤和DNA损伤检查点的激活。
2. BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. [J] . Yu X, Fu S, Lai M, Genes and Development: a Journal Devoted to the Molecular Analysis of Gene Expression in Eukaryotes, Prokaryotes, and Viruses . 2006,第13期

机译：BRCA1泛素化其依赖磷酸化的结合伴侣CtIP。
3. Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex [J] . Varma AK, Brown RS, Birrane G, Biochemistry . 2005,第33期

机译：BRCA1-CTIP复合体的细胞周期检查点控制的结构基础
4. DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells [C] . Karin N. Kleinhans, Martin D. Burkhalter Else Kro?ner-Fresenius Symposium on the Advances in Stem Cell Aging . 2012

机译：老化干细胞中的DNA损伤，检查点反应和细胞周期控制
5. DNA damage-induced cell cycle checkpoints as a target for cancer therapy. [D] . Kohn, Ethan Alfred. 2004

机译：DNA损伤诱导的细胞周期检查点作为癌症治疗的目标。
6. DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains [O] . Xiaochun Yu, Junjie Chen 2004

机译：DNA损伤诱导的细胞周期检查点控制需要CtIPBRCA1 C末端域的磷酸化依赖性结合伙伴。
7. DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains [O] . Yu, Xiaochun, Chen, Junjie 2004

机译：DNA损伤诱导的细胞周期检查点控制需要CtIP，BRCA1 C末端域的磷酸化依赖性结合伙伴。
8. Involvement of 53BP1, a p53 Binding Protein, in Chk2 Phosphyorylation of p53 and DNA Damage Cell Cycle Checkpoints [R] . Wang, B. 2006

机译：p53结合蛋白53Bp1参与p53和DNa损伤的Chk2磷酸化细胞周期检查点

DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

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