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首页> 外文期刊>Molecular and Cellular Biology >The Sox-2 Regulatory Regions Display Their Activities in Two Distinct Types of Multipotent Stem Cells
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The Sox-2 Regulatory Regions Display Their Activities in Two Distinct Types of Multipotent Stem Cells

机译：Sox-2调节区在两种不同类型的多能干细胞中显示其活性。

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The Sox-2 gene is expressed in embryonic stem (ES) cells and neural stem cells. Two transcription enhancer regions, Sox-2 regulatory region 1 (SRR1) and SRR2, were described previously based on their activities in ES cells. Here, we demonstrate that these regulatory regions also exert their activities in neural stem cells. Moreover, our data reveal that, as in ES cells, both SRR1 and SRR2 show their activities rather specifically in multipotent neural stem or progenitor cells but cease to function in differentiated cells, such as postmitotic neurons. Systematic deletion and mutation analyses showed that the same or at least overlapping DNA elements of SRR2 are involved in its activity in both ES and neural stem or progenitor cells. Thus, SRR2 is the first example of an enhancer in which a single regulatory core sequence is involved in multipotent-state-specific expression in two different stem cells, i.e., ES and neural stem cells.
机译： Sox-2 基因在胚胎干（ES）细胞和神经干细胞中表达。之前根据它们在ES细胞中的活性描述了两个转录增强子区域，即Sox-2调节区1（SRR1）和SRR2。在这里，我们证明了这些调节区域在神经干细胞中也发挥了作用。此外，我们的数据显示，与ES细胞一样，SRR1和SRR2都在多能神经干细胞或祖细胞中显示其活性，但在分化细胞（如有丝分裂后的神经元）中不再起作用。系统的缺失和突变分析表明，SRR2的相同或至少重叠的DNA元素在ES和神经干细胞或祖细胞中均参与其活性。因此，SRR2是增强子的第一个例子，其中单个调节核心序列参与两个不同干细胞即ES和神经干细胞的多能态特异性表达。

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