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首页> 外文期刊>Molecular and Cellular Biology >Loss of the Putative Tumor Suppressor Band 4.1B/Dal1 Gene Is Dispensable for Normal Development and Does Not Predispose to Cancer
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Loss of the Putative Tumor Suppressor Band 4.1B/Dal1 Gene Is Dispensable for Normal Development and Does Not Predispose to Cancer

机译：推定的肿瘤抑制带4.1B / Dal1基因的丢失是正常发育必不可少的，并不易患癌症

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摘要

The band 4.1 proteins are cytoskeletal proteins, harboring a conserved FERM domain highly homologous to the N-terminal FERM domain of ezrin, radixin, moesin, and merlin. Recently, a truncated form of the 4.1B protein, termed Dal-1, was identified in a screen as down regulated in adenocarcinoma of the lung and was mapped to chromosome 18p11.3, which is lost in 38% of primary non-small cell lung carcinoma tumors. Analysis of several meningiomas has shown that Dal-1 expression was lost in 76% of the tumors. To further elucidate the function of the 4.1B/Dal-1 gene in development and tumorigenesis we generated mice deficient for this allele. The 4.1B/Dal-1 null mice develop normally and are fertile. Rates of cellular proliferation and apoptosis in brain, mammary, and lung tissues from the 4.1B/Dal-1 null mice were indistinguishable from those seen with wild-type mice. Aging studies indicate that these mice do not have a propensity to develop tumors. Analysis of fibroblasts from these mice demonstrated that the growth characteristics and kinetics of these cells were not different from those of cells from the wild-type mice. These findings indicate that the 4.1B gene is not required for normal development and that 4.1B/Dal-1 does not function as a tumor suppressor gene.
机译：带4.1蛋白是细胞骨架蛋白，具有与ezrin，radixin，moesin和merlin的N-末端FERM结构域高度同源的保守FERM结构域。最近，在屏幕上发现截短形式的称为Dal-1的4.1B蛋白在肺腺癌中被下调，并定位到18p11.3号染色体上，该染色体在38％的原发性非小细胞中丢失肺癌肿瘤。对几种脑膜瘤的分析表明，Dal-1表达在76％的肿瘤中丢失。为了进一步阐明4.1B / Dal-1基因在发育和肿瘤发生中的功能，我们生成了缺乏该等位基因的小鼠。 4.1B / Dal-1无效小鼠正常发育且可育。来自4.1B / Dal-1无效小鼠的脑，乳腺和肺组织的细胞增殖和凋亡率与野生型小鼠没有区别。衰老研究表明，这些小鼠不具有发展肿瘤的倾向。对来自这些小鼠的成纤维细胞的分析表明，这些细胞的生长特性和动力学与野生型小鼠的细胞没有变化。这些发现表明4.1B基因对于正常发育不是必需的，并且4.1B / Dal-1不作为肿瘤抑制基因。

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