A novel POU domain protein which binds to the T-cell receptor beta enhancer.

H Messier; H Brickner; J Gaikwad; A Fotedar

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A novel POU domain protein which binds to the T-cell receptor beta enhancer.

机译：与T细胞受体β增强剂结合的新型POU域蛋白。

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POU domain proteins have been implicated in the regulation of a number of lineage-specific genes. Among the first POU domain proteins described were the immunoglobulin octamer-binding proteins Oct-1 and Oct-2. It was therefore of special interest when we identified a novel lymphoid POU domain protein in Southwestern (DNA-protein) screens of T-cell lambda gt11 libraries. This novel POU protein, TCF beta 1, binds in a sequence-specific manner to a critical motif in the T-cell receptor (TCR) beta enhancer. Sequence analysis revealed that TCF beta 1 represents a new class of POU domain proteins which are distantly related to other POU proteins. TCF beta 1 is encoded by multiple exons whose organization is distinct from that of other POU domain proteins. The expression of TCF beta 1 in a tissue-restricted manner and its ability to bind to multiple motifs in the TCR beta enhancer support a role in regulating TCR beta gene expression. The expression of TCF beta 1 in both B and T cells and the ability of recombinant TCF beta 1 to bind octamer and octamer-related motifs suggest that TCF beta 1 has additional roles in lymphoid cell function. The ability of TCF beta 1 to transactivate in a sequence-specific manner is consistent with a role for regulating lymphoid gene expression.

机译：POU域蛋白已牵涉到许多谱系特异性基因的调控。所述的第一个POU结构域蛋白是免疫球蛋白八聚体结合蛋白Oct-1和Oct-2。因此，当我们在T细胞lambda gt11文库的西南筛选（DNA蛋白）中发现一个新颖的淋巴POU结构域蛋白时，就引起了特别的兴趣。这种新颖的POU蛋白TCF beta 1以序列特异性的方式与T细胞受体（TCR）beta增强子中的关键基序结合。序列分析表明，TCF beta 1代表了一类新的POU域蛋白，与其他POU蛋白之间的距离遥远。 TCF beta 1由多个外显子编码，它们的组织结构不同于其他POU域蛋白。 TCF beta 1的组织限制性表达及其与TCR beta增强子中多个基序结合的能力支持了调节TCR beta基因表达的作用。 TCF beta 1在B细胞和T细胞中的表达以及重组TCF beta 1结合八聚体和与八聚体相关的基序的能力表明TCF beta 1在淋巴样细胞功能中具有其他作用。 TCF beta 1以序列特异性方式反式激活的能力与调节淋巴样基因表达的作用一致。

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《Molecular and Cellular Biology》 |1993年第9期|共11页
作者
H Messier; H Brickner; J Gaikwad; A Fotedar;
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中图分类细胞生物学;
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机译：Discoidin域受体1的激活通过TNF受体相关因子6 / TGF-beta激活的蛋白激酶1结合蛋白1beta / p38alpha丝裂原激活的蛋白K促进人类单核细胞衍生的树突状细胞的成熟。
2. c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer. [J] . C Hernandez-Munain, M S Krangel Molecular and Cellular Biology . 1995,第6期

机译：c-Myb和核心结合因子/ PEBP2显示功能协同作用，但独立地与T细胞受体δ增强子中的相邻位点结合。
3. c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer. [J] . C Hernandez-Munain, M S Krangel Molecular and Cellular Biology . 1995,第6期

机译：c-Myb和核心结合因子/ PEBP2显示功能协同作用，但独立地与T细胞受体δ增强子中的相邻位点结合。
4. Conservation and Network Analysis of the (4beta+alpha) Fold of the Immunoglobulin-Binding B1 Domain of Protein G to Elucidate the Key Determinants of Structure, Folding and Stability [C] . Jason C. Collins, John Bedford, Lesley H. Greene ISBRA 2013 . 2015

机译：蛋白G免疫球蛋白结合B1结构域的（4Beta +α）折叠的保护和网络分析，以阐明结构，折叠和稳定性的关键决定因素
5. Biophysical characterization of zinc(II)-binding domains in two systems: Neural zinc finger factor-1 and T-cell co-receptors DC4 and DC8 alpha with T-cell-specific kinase Lck. [D] . Davis, Alisa M. 2007

机译：锌（II）结合域在两个系统中的生物物理特征：神经锌指因子1和T细胞共受体DC4和DC8α与T细胞特异性激酶Lck。
6. A novel POU domain protein which binds to the T-cell receptor beta enhancer. [O] . H Messier, H Brickner, J Gaikwad, 1985

机译：与T细胞受体β增强剂结合的新型POU域蛋白。
7. A novel POU domain protein which binds to the T-cell receptor beta enhancer. [O] . Messier, H, Brickner, H, Gaikwad, J, 1993

机译：与T细胞受体β增强剂结合的新型POU域蛋白。
8. Characterization of Novel Seven Transmembrane Helix, GS-Coupled Receptors and Pou Domain Proteins in Cancer of the Mammary Epithelium [R] . Rosenfeld, M. G. 1998

机译：新型七跨膜螺旋，Gs偶联受体和pou结构域蛋白在乳腺上皮癌中的表征

A novel POU domain protein which binds to the T-cell receptor beta enhancer.

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