Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae.

F Estruch; M Carlson

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Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae.

机译：通过酿酒酵母的SNF1蛋白激酶突变体中的多拷贝抑制鉴定出的两个同源锌指基因。

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The MSN2 gene was selected as a multicopy suppressor in a temperature-sensitive SNF1 protein kinase mutant of Saccharomyces cerevisiae. MSN2 encodes a Cys2His2 zinc finger protein related to the yeast MIG1 repressor and to mammalian early growth response and Wilms' tumor zinc finger proteins. Deletion of MSN2 caused no phenotype. A second similar zinc finger gene, MSN4, was isolated, and deletion of both genes caused phenotypic defects related to carbon utilization. Overexpression of the zinc finger regions was deleterious to growth. LexA-MSN2 and LexA-MSN4 fusion proteins functioned as strong transcriptional activators when bound to DNA. Functional roles of this zinc finger protein family are discussed.

机译：在酿酒酵母的温度敏感性SNF1蛋白激酶突变体中，选择MSN2基因作为多拷贝抑制剂。 MSN2编码Cys2His2锌指蛋白，该蛋白与酵母MIG1阻遏物，哺乳动物早期生长反应和Wilms的肿瘤锌指蛋白有关。 MSN2的删除没有引起表型。分离出第二个相似的锌指基因MSN4，两个基因的缺失引起与碳利用有关的表型缺陷。锌指区域的过表达对生长有害。 LexA-MSN2和LexA-MSN4融合蛋白在与DNA结合时起着强大的转录激活剂的作用。锌指蛋白家族的功能作用进行了讨论。

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《Molecular and Cellular Biology》 |1993年第7期|共10页
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F Estruch; M Carlson;
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中图分类细胞生物学;
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1. Use of a screen for synthetic lethal and multicopy suppressee mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae. [J] . A Bender, J R Pringle Molecular and Cellular Biology . 1991,第3期

机译：筛选合成致死和多拷贝受抑制者突变体的方法，以鉴定酿酒酵母中涉及形态发生的两个新基因。
2. A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5. [J] . K Kitada, A L Johnson, L H Johnston, Molecular and Cellular Biology . 1993,第7期

机译：啤酒酵母G1细胞周期突变基因dbf4的多拷贝抑制基因编码一个蛋白激酶，被鉴定为CDC5。
3. Characterization of tobacco protein kinase NPK5, a homolog of Saccharomyces cerevisiae SNF1 that constitutively activates expression of the glucose-repressible SUC2 gene for a secreted invertase of S. cerevisiae. [J] . T Muranaka, H Banno, Y Machida Molecular and Cellular Biology . 1994,第5期

机译：烟草蛋白激酶NPK5（啤酒酵母SNF1的同系物）的特征，该酶可组成性地激活酿酒酵母分泌型转化酶的葡萄糖可抑制SUC2基因的表达。
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5. New Vistas in Zinc Finger Biochemistry: Examining the Metal-Mediated DNA Recognition of the Neural Zinc Finger Factor/Myelin Transcription Factor Family of Non-Classical Zinc Finger Proteins and Creating Catalytic Moieties from Zinc Finger Scaffolds [D] . Besold, Angelique N. 2014

机译：锌指生物化学的新视野：检查非经典锌指蛋白的神经锌指因子/髓鞘转录因子家族的金属介导的DNA识别，并从锌指支架中产生催化部分
6. Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae. [O] . F Estruch, M Carlson 1993

机译：通过酿酒酵母的SNF1蛋白激酶突变体中的多拷贝抑制鉴定的两个同源锌指基因。
7. Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae. [O] . Estruch, F, Carlson, M 1993

机译：通过酿酒酵母的SNF1蛋白激酶突变体中的多拷贝抑制鉴定的两个同源锌指基因。

Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae.

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