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首页> 外文期刊>Molecular and Cellular Biology >MCM1 binds to a transcriptional control element in Ty1.
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MCM1 binds to a transcriptional control element in Ty1.

机译：MCM1绑定到Ty1中的转录控制元件。

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摘要

Some Ty1 transposable-element insertion mutations of Saccharomyces cerevisiae activate adjacent-gene expression. These Ty1-activated genes are regulated similarly to certain mating genes. This report shows that the MCM1 protein, which binds to several mating genes, also binds to a transcriptional regulatory sequence in Ty1. The binding of MCM1 to Ty1 correlates with the ability of its binding site to function as a component of the Ty1 transcriptional activator. This correlation supports the idea that MCM1 is important for Ty1-activated gene expression. At mating-gene promoters, MCM1 binds with coactivators or repressors such as STE12, alpha 1, or alpha 2. In contrast, MCM1 binds without these associated DNA-binding proteins at its site in Ty1. This finding suggests that its role in Ty1-mediated transcription is different from that at mating genes.
机译：酿酒酵母的某些Ty1转座子插入突变激活邻近基因的表达。这些Ty1激活基因的调控与某些交配基因相似。该报告显示，与多个交配基因结合的MCM1蛋白也与Ty1中的转录调控序列结合。 MCM1与Ty1的结合与其结合位点作为Ty1转录激活因子组分的能力有关。这种相关性支持MCM1对Ty1激活的基因表达很重要的想法。在交配基因启动子处，MCM1与共激活物或阻遏物（例如STE12，α1或α2）结合。相反，MCM1在Ty1的位点结合而没有这些相关的DNA结合蛋白。这一发现表明，它在Ty1介导的转录中的作用与交配基因中的作用不同。

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