A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter.

D D Duncan; A Stupakoff; S M Hedrick; K B Marcu; G Siu

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A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter.

机译：Myc相关的锌指蛋白结合位点是CD4启动子中的四个重要功能区域之一。

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The CD4 promoter plays an important role in the developmental control of CD4 transcription. In this report, we show that the minimal CD4 promoter has four factor binding sites, each of which is required for full function. Using biochemical and mutagenesis analyses, we determined that multiple nuclear factors bind to these independent sites. We determined that an initiator-like sequence present at the cap site and an Ets consensus sequence are required for full promoter function. We also demonstrate that the Myc-associated zinc finger protein (MAZ) appears to be the predominant factor binding to one of these sites. This last site closely resembles the ME1a1 G3AG4AG3 motif previously shown to be a critical element in the P2 promoter of the c-myc gene. We therefore believe that the MAZ transcription factor is also likely to play an important role in the control of developmental expression of the CD4 gene.

机译：CD4启动子在CD4转录的发育控制中起重要作用。在此报告中，我们显示了最小的CD4启动子具有四个因子结合位点，每个位点都是完整功能所必需的。使用生化和诱变分析，我们确定了多个核因子与这些独立位点结合。我们确定存在于帽位点的启动子样序列和Ets共有序列是完整启动子功能所必需的。我们还证明，与Myc相关的锌指蛋白（MAZ）似乎是与这些位点之一结合的主要因子。最后一个位点非常类似于先前显示为c-myc基因P2启动子中的关键元件的ME1a1 G3AG4AG3基序。因此，我们认为，MAZ转录因子也可能在控制CD4基因的发育表达中起重要作用。

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《Molecular and Cellular Biology》 |1995年第6期|共8页
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D D Duncan; A Stupakoff; S M Hedrick; K B Marcu; G Siu;
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中图分类细胞生物学;
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4. Evidence for the presence of a secondary binding site between HIV-MN-gp120 PND and the CD4 CDR3 region [C] . Monica Dettin, Gianluca Picariello, Claudia Scarinci, European Peptide Symposium . 2002

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5. Metal-binding properties of the zinc fingers in metal responsive element-binding transcription factor-1 and design of single-stranded nucleic acid binding proteins using nucleocapsid-like CCHC zinc-binding domains. [D] . Guerrerio, Anthony Lawrence, Jr. 2004

机译：锌指在金属反应元件结合转录因子-1中的金属结合特性，以及使用核衣壳样CCHC锌结合结构域设计单链核酸结合蛋白。
6. A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter. [O] . D D Duncan, A Stupakoff, S M Hedrick, 1995

机译：Myc相关的锌指蛋白结合位点是CD4启动子中的四个重要功能区域之一。
7. A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter. [O] . Duncan, D D, Stupakoff, A, Hedrick, S M, 1995

机译：Myc相关的锌指蛋白结合位点是CD4启动子中的四个重要功能区域之一。

A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter.

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