Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins.

N Mathias; S L Johnson; M Winey; A E Adams; L Goetsch; J R Pringle; B Byers; M G Goebl

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Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins.

机译：Cdc53p与Cdc4p和Cdc34p协同作用，以控制G1到S相的转变，并鉴定出一个保守的蛋白质家族。

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Regulation of cell cycle progression occurs in part through the targeted degradation of both activating and inhibitory subunits of the cyclin-dependent kinases. During G1, CDC4, encoding a WD-40 repeat protein, and CDC34, encoding a ubiquitin-conjugating enzyme, are involved in the destruction of these regulators. Here we describe evidence indicating that CDC53 also is involved in this process. Mutations in CDC53 cause a phenotype indistinguishable from those of cdc4 and cdc34 mutations, numerous genetic interactions are seen between these genes, and the encoded proteins are found physically associated in vivo. Cdc53p defines a large family of proteins found in yeasts, nematodes, and humans whose molecular functions are uncharacterized. These results suggest a role for this family of proteins in regulating cell cycle proliferation through protein degradation.

机译：细胞周期进程的调节部分通过细胞周期蛋白依赖性激酶的激活和抑制亚基的靶向降解而发生。在G1期间，编码WD-40重复蛋白的CDC4和编码泛素结合酶的CDC34参与了这些调节剂的破坏。在这里，我们描述了表明CDC53也参与该过程的证据。 CDC53中的突变导致其表型与cdc4和cdc34突变的表型没有区别，在这些基因之间发现了许多遗传相互作用，并且发现编码的蛋白在体内具有物理联系。 Cdc53p定义了在酵母，线虫和人类中发现的一大类蛋白质，这些蛋白质的分子功能未得到表征。这些结果表明该蛋白家族在通过蛋白降解调节细胞周期增殖中的作用。

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《Molecular and Cellular Biology》 |1996年第12期|共10页
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N Mathias; S L Johnson; M Winey; A E Adams; L Goetsch; J R Pringle; B Byers; M G Goebl;
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中图分类细胞生物学;
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1. Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins. [J] . N Mathias, S L Johnson, M Winey, Molecular and Cellular Biology . 1996,第12期

机译：Cdc53p与Cdc4p和Cdc34p协同作用，以控制G1到S相的转变，并鉴定出一个保守的蛋白质家族。
2. Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins. [J] . Takaki S, Sauer K, Iritani BM, Immunity . 2000,第5期

机译：通过衔接蛋白lnk控制B细胞产生。保守的信号调节蛋白家族的定义。
3. NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G0/G1-to-S-Phase Transition [J] . Michael Hinz, Daniel Krappmann, Alexandra Eichten, Molecular and Cellular Biology . 1999,第4期

机译：NF-κB在生长控制中的功能：细胞周期蛋白D1表达和G0 / G1-S相过渡的调节。
4. Identifying Highly Conserved Blocks in Families of Biosequences Through Selective Extensions [C] . Jaime Seguel, Yaisiel Torres International Conference on Bioinformatics and Computational Biology . 2010

机译：通过选择性扩展识别生物姿态家庭的高度保守障碍
5. Analyses of alternative splicing and deletion mutants identify an inhibitory domain in human transcription factor REL, an oncogenic member of the NF-kappaB family of proteins. [D] . Leeman, Joshua R. 2009

机译：选择性剪接和缺失突变体的分析确定了人类转录因子REL（NF-κB蛋白家族的致癌成员）中的抑制域。
6. Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins. [O] . N Mathias, S L Johnson, M Winey, 1996

机译：Cdc53p与Cdc4p和Cdc34p协同作用以控制G1到S相的转变并鉴定出一个保守的蛋白质家族。
7. Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins. [O] . Mathias, N, Johnson, S L, Winey, M, 1996

机译：Cdc53p与Cdc4p和Cdc34p协同作用，以控制G1到S相的转变，并鉴定出一个保守的蛋白质家族。

Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins.

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