Transcriptional Activation of the Cyclin A Gene by the Architectural Transcription Factor HMGA2

Michela A. Tessari; Monica Gostissa; Sandro Altamura; Riccardo Sgarra; Alessandra Rustighi; Clio Salvagno; Giuseppina Caretti; Carol Imbriano; Roberto Mantovani; Giannino Del Sal; Vincenzo Giancotti; Guidalberto Manfioletti

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Transcriptional Activation of the Cyclin A Gene by the Architectural Transcription Factor HMGA2

机译：建筑转录因子HMGA2对cyclin A基因的转录激活。

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The HMGA2 protein belongs to the HMGA family of architectural transcription factors, which play an important role in chromatin organization. HMGA proteins are overexpressed in several experimental and human tumors and have been implicated in the process of neoplastic transformation. Hmga2 knockout results in the pygmy phenotype in mice and in a decreased growth rate of embryonic fibroblasts, thus indicating a role for HMGA2 in cell proliferation. Here we show that HMGA2 associates with the E1A-regulated transcriptional repressor p120E4F, interfering with p120E4F binding to the cyclin A promoter. Ectopic expression of HMGA2 results in the activation of the cyclin A promoter and induction of the endogenous cyclin A gene. In addition, chromatin immunoprecipitation experiments show that HMGA2 associates with the cyclin A promoter only when the gene is transcriptionally activated. These data identify the cyclin A gene as a cellular target for HMGA2 and, for the first time, suggest a mechanism for HMGA2-dependent cell cycle regulation.

机译：HMGA2蛋白属于建筑转录因子HMGA家族，在染色质组织中起重要作用。 HMGA蛋白在几种实验性和人类肿瘤中均过表达，并与肿瘤转化过程有关。 Hmga2 基因敲除可导致小鼠 pygmy 表型，并降低胚胎成纤维细胞的生长速率，从而表明HMGA2在细胞增殖中的作用。在这里，我们显示HMGA2与E1A调控的转录阻遏物p120 E4F 相关联，干扰p120 E4F 与细胞周期蛋白A启动子的结合。 HMGA2的异位表达导致细胞周期蛋白A启动子的激活和内源性细胞周期蛋白A基因的诱导。此外，染色质免疫沉淀实验表明，仅当基因被转录激活时，HMGA2才与细胞周期蛋白A启动子结合。这些数据将细胞周期蛋白A基因鉴定为HMGA2的细胞靶标，并首次提出了依赖HMGA2的细胞周期调控机制。 展开▼

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《Molecular and Cellular Biology》 |2003年第24期|共13页

作者
Michela A. Tessari; Monica Gostissa; Sandro Altamura; Riccardo Sgarra; Alessandra Rustighi; Clio Salvagno; Giuseppina Caretti; Carol Imbriano; Roberto Mantovani; Giannino Del Sal; Vincenzo Giancotti; Guidalberto Manfioletti;
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中图分类细胞生物学;

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1. The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression. [J] . Yu JH, Zhu BM, Wickre M, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2010,第5期

机译：转录因子信号转导子和转录激活子5A（STAT5A）和STAT5B通过激活细胞周期蛋白依赖性激酶抑制剂2b（Cdkn2b）和Cdkn1a表达来负调控细胞增殖。

2. The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function [J] . Cattaruzzi G, Altamura S, Tessari MA, Nucleic Acids Research . 2007,第6期

机译：结构转录因子HMGA2的第二个AT钩决定核的定位和功能

3. The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function [J] . Alessandra Rustighi, Carlo Pucillo, Giacomo Cattaruzzi, Nucleic acids research . 2007,第6期

机译：建筑转录因子HMGA2的第二个钩子是核定位和功能的决定因素

4. In-depth activated transcription factor profiling with a concatenated tandem array of transcription factor response elements [C] . Chen Ding, Wanlin Liu, Dong Li, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：深入活化的转录因子分布，转录因子响应元件的连接串联阵列

5. The effect of iron-containing particulates on induction and activity of the transcription factors nuclear factor κB, early growth response 1, and activating transcription factor 3 in human lung epithelial cells [D] . Buelow, Laura Cecile 2007

机译：含铁颗粒物对人肺上皮细胞转录因子核因子κB的诱导和活性，早期生长反应1和活化转录因子3的影响

6. Transcriptional Activation of the Cyclin A Gene by the Architectural Transcription Factor HMGA2 [O] . Michela A. Tessari, Monica Gostissa, Sandro Altamura, 2003

机译：建筑转录因子HMGA2对cyclin A基因的转录激活

7. Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2 [O] . Tessari MA, Gostissa M, Altamura S, 2003

机译：建筑转录因子HMGA2对cyclin A基因的转录激活

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6. 一溴二氯甲烷通过高甲基化抑制E-cadherin基因的表达或转录激活c-myc和cyclin D1基因的机制来诱导雄性F344大鼠不同脏器的细胞增殖 [C] . Jing Liao ,廖静 ,XiaofengLi . 2013年广东省职业卫生学年会暨广东省职业健康协会首届学术交流会 . 2013

7. 组蛋白乙酰化增强转录因子Spl诱导的mda-7基因转录激活 [A] . 潘虹 . 2011

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2. 具有抑制转录因子的转录激活活性的多肽及其编码基因与应用 [P] . 中国专利： CN101538322A . 2009-09-23

3. Transcription factors, transcription factor gene, a recombinant vector comprising the transcription factor gene, use of the koji mold Aspergillus oryzae, and that is transformed by the vector [P] . 外国专利： JP4029927B2 . 2008-01-09

机译：转录因子，转录因子基因，包含该转录因子基因的重组载体，曲霉米曲霉的用途以及被载体转化的载体

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机译：转录因子，转录因子基因，包含转录因子基因的重组矢量，经矢量转化的KOJI-MOLD和使用KOJI-MOLD的方法

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机译：转录因子，转录因子基因，包含转录因子基因的重组矢量，经矢量转化的KOJI-MOLD和使用KOJI-MOLD的方法

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Transcriptional Activation of the Cyclin A Gene by the Architectural Transcription Factor HMGA2

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