A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation.

J N Feder; L Y Jan; Y N Jan

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A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation.

机译：与果蝇多毛的果蝇具有序列同源性的大鼠基因被已知会影响神经元分化的生长因子迅速诱导。

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Several genes encoding transcription factors with a helix-loop-helix (HLH) motif are involved in the early process of neural development in Drosophila spp. We report the isolation from the rat a homolog of one of these genes, called hairy. The rat-hairy-like (RHL) gene is expressed early during embryogenesis. In contrast to the restricted expression of hairy mRNA in Drosophila spp., however, the mRNA encoded by RHL is detectable in all tissues examined. Stimulation of PC12 pheochromocytoma cells by nerve growth factor, basis fibroblast growth factor, or epidermal growth factor or of Rat-1 fibroblasts by epidermal growth factor causes a rapid and transient induction of the RHL gene. Thus, RHL acts as an immediate-early gene that can potentially transduce growth factor signals during the development of the mammalian embryo.

机译：果蝇属的神经发育的早期过程涉及几个编码具有螺旋-环-螺旋（HLH）主题的转录因子的基因。我们报告从大鼠中分离出这些基因之一的同源物，称为多毛。大鼠毛状（RHL）基因在胚胎发生过程中早期表达。与果蝇属中毛状mRNA的限制性表达相反，RHL编码的mRNA在所有检查的组织中均可检测到。神经生长因子，基础成纤维细胞生长因子或表皮生长因子刺激PC12嗜铬细胞瘤细胞或表皮生长因子刺激Rat-1成纤维细胞引起RHL基因的快速和瞬时诱导。因此，RHL可以作为早期基因，可以在哺乳动物胚胎发育过程中潜在地转导生长因子信号。

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《Molecular and Cellular Biology》 |1993年第1期|共9页
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J N Feder; L Y Jan; Y N Jan;
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中图分类细胞生物学;
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6. A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation. [O] . J N Feder, L Y Jan, Y N Jan 1993

机译：与果蝇多毛的果蝇具有序列同源性的大鼠基因被已知影响神经元分化的生长因子迅速诱导。
7. A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation. [O] . Feder, J N, Jan, L Y, Jan, Y N 1993

机译：与果蝇多毛的果蝇具有序列同源性的大鼠基因被已知影响神经元分化的生长因子迅速诱导。

A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation.

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