Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expression.

R R Rivera; M H Stuiver; R Steenbergen; C Murre

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Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expression.

机译：Ets蛋白：调节免疫球蛋白重链基因表达的新因子。

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We used a DNA-protein interaction screening method to isolate a cDNA, Erg-3, whose product binds to a site, designated pi, present in the immunoglobulin (Ig) heavy-chain gene enhancer. Erg-3 is an alternatively spliced product of the erg gene and contains an Ets DNA-binding domain. Fli-1 and PU.1, related Ets proteins, also bind to the same site. In addition, PU.1 binds to a second site, designated microB, in the Ig heavy-chain enhancer. We demonstrate that the pi binding site is crucial for Ig heavy-chain gene enhancer function. In addition, we show that Erg-3 and Fli.1, but not PU.1, can activate a reporter construct containing a multimer of protein-binding sites, synergistically with helix-loop-helix protein E12. We discuss how combinatorial interactions between members of the helix-loop-helix and Ets families may account for the tissue specificity of these proteins.

机译：我们使用了一种DNA-蛋白质相互作用筛选方法来分离cDNA Erg-3，其产物与免疫球蛋白（Ig）重链基因增强子中存在的位点pi结合。 Erg-3是erg基因的另一种剪接产物，包含一个Ets DNA结合域。相关的Ets蛋白Fli-1和PU.1也与同一位点结合。此外，PU.1与Ig重链增强子中的第二个位点结合，称为microB。我们证明了pi结合位点对于Ig重链基因增强子功能至关重要。此外，我们显示Erg-3和Fli.1，而不是PU.1，可以激活包含螺旋结合环蛋白E12的蛋白质结合位点多聚体的报告基因构建体。我们讨论了螺旋-环-螺旋和Ets家族成员之间的组合相互作用如何解释这些蛋白质的组织特异性。

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《Molecular and Cellular Biology》 |1993年第11期|共7页
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R R Rivera; M H Stuiver; R Steenbergen; C Murre;
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中图分类细胞生物学;
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3. Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78?kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation [J] . Amy S. LEE, Shengzhan LUO The biochemical journal . 2002,第3期

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6. Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expression. [O] . R R Rivera, M H Stuiver, R Steenbergen, 1993

机译：Ets蛋白：调节免疫球蛋白重链基因表达的新因子。
7. Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expression. [O] . Rivera, R R, Stuiver, M H, Steenbergen, R, 1993

机译：Ets蛋白：调节免疫球蛋白重链基因表达的新因子。

Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expression.

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