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首页> 外文期刊>Molecular and Cellular Biology >Two novel transmembrane protein tyrosine kinases expressed during Caenorhabditis elegans hypodermal development.
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Two novel transmembrane protein tyrosine kinases expressed during Caenorhabditis elegans hypodermal development.

机译：在秀丽隐杆线虫皮下发育过程中表达的两个新型跨膜蛋白酪氨酸激酶。

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We describe our characterization of kin-15 and kin-16, a tandem pair of homologous Caenorhabditis elegans genes encoding transmembrane protein tyrosine kinases (PTKs) with an unusual structure: the predicted extracellular domain of each putative gene product is only about 50 amino acids, and there are no potential autophosphorylation sites in the C-terminal domain. Using lacZ fusions, we found that kin-15 and kin-16 both appear to be expressed during postembryonic development in the large hypodermal syncytium (hyp7) around the time that specific hypodermal cells fuse with hyp7. kin-15 and kin-16 were positioned on the genetic and physical maps, but extrachromosomal arrays containing wild-type kin-15 and/or kin-16 genes were unable to complement candidate lethal mutations. The results suggest that kin-15 and kin-16 may be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development.
机译：我们描述了kin-15和kin-16的表征，这是一对编码不透明结构的跨膜蛋白酪氨酸激酶（PTK）的同源秀丽隐杆线虫基因：每个推定基因产物的预测胞外域仅约50个氨基酸，并且在C末端域中没有潜在的自磷酸化位点。使用lacZ融合，我们发现kin-15和kin-16都在特定的皮下细胞与hyp7融合的时间在大型皮下合胞体（hyp7）的胚后发育过程中表达。 kin-15和kin-16定位在遗传图谱和物理图谱上，但是包含野生型kin-15和/或kin-16基因的染色体外阵列无法补充候选致死突变。结果表明，kin-15和kin-16可能特别参与调节细胞融合的细胞间相互作用，该融合在胚后发育过程中产生皮下组织。

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