Binding of NCK to SOS and activation of ras-dependent gene expression.

Q Hu; D Milfay; L T Williams

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Binding of NCK to SOS and activation of ras-dependent gene expression.

机译：NCK与SOS的结合以及ras依赖性基因表达的激活。

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NCK, an SH2- and SH3 domain-containing protein, becomes phosphorylated and associated with tyrosine kinase receptors upon growth factor stimulation. The sequence of NCK suggests that NCK functions as a linker between receptors and a downstream signaling molecule. To determine if NCK can mediate growth factor-stimulated responses, we measured the ability of NCK to activate the fos promoter. We found that in NIH 3T3 cells, NCK strongly activates this promoter. The effect of NCK on the fos promoter is enhanced by c-ras and blocked by dominant negative ras. We also found that NCK binds directly to the guanine nucleotide exchange factor SOS. This interaction is mediated by the SH3 domains of NCK. These findings suggest that NCK can regulate p21ras-dependent gene transcription through interaction with SOS protein.

机译：NCK是一种含有SH2和SH3结构域的蛋白，在生长因子刺激后会被磷酸化并与酪氨酸激酶受体相关。 NCK的序列表明NCK充当受体和下游信号分子之间的连接子。为了确定NCK是否可以介导生长因子刺激的应答，我们测量了NCK激活fos启动子的能力。我们发现在NIH 3T3细胞中，NCK强烈激活了该启动子。 NCK对fos启动子的作用被c-ras增强并被显性负ras阻断。我们还发现NCK直接与鸟嘌呤核苷酸交换因子SOS结合。这种相互作用是由NCK的SH3结构域介导的。这些发现表明，NCK可通过与SOS蛋白相互作用来调节p21ras依赖性基因的转录。

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《Molecular and Cellular Biology》 |1995年第3期|共6页
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Q Hu; D Milfay; L T Williams;
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中图分类细胞生物学;
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6. Binding of NCK to SOS and activation of ras-dependent gene expression. [O] . Q Hu, D Milfay, L T Williams 1995

机译：NCK与SOS的结合以及ras依赖性基因表达的激活。
7. Binding of NCK to SOS and activation of ras-dependent gene expression. [O] . Hu, Q, Milfay, D, Williams, L T 1995

机译：NCK与SOS的结合以及ras依赖性基因表达的激活。
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Binding of NCK to SOS and activation of ras-dependent gene expression.

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