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Independent Recruitment of Mediator and SAGA by the Activator Met4

机译：Met4激活程序独立招聘中介者和SAGA

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摘要

Mediator is a key RNA polymerase II (Pol II) cofactor in the regulation of eukaryotic gene expression. It is believed to function as a coactivator linking gene-specific activators to the basal Pol II initiation machinery. In support of this model, we provide evidence that Mediator serves in vivo as a coactivator for the yeast activator Met4, which controls the gene network responsible for the biosynthesis of sulfur-containing amino acids and S-adenosylmethionine. In addition, we show that SAGA (Spt-Ada-Gcn5-acetyltransferase) is also recruited to Met4 target promoters, where it participates in the recruitment of Pol II by a mechanism involving histone acetylation. Interestingly, we find that SAGA is not required for Mediator recruitment by Met4 and vice versa. Our results provide a novel example of functional interplay between Mediator and coactivators involved in histone modification.
机译：介体是调节真核基因表达的关键RNA聚合酶II（Pol II）辅助因子。据信它起着将基因特异性激活剂连接至基础Pol II起始机制的共激活剂的作用。为支持该模型，我们提供了证据，证明介体在体内充当酵母活化剂Met4的共活化剂，后者控制着负责含硫氨基酸和 S -腺苷甲硫氨酸生物合成的基因网络。此外，我们显示SAGA（Spt-Ada-Gcn5-乙酰基转移酶）也被募集到Met4目标启动子，在其中它通过涉及组蛋白乙酰化的机制参与Pol II的募集。有趣的是，我们发现Met4招聘Mediator并不需要SAGA，反之亦然。我们的研究结果提供了介导组蛋白修饰的介体和共激活因子之间功能相互作用的新例子。

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