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首页> 外文期刊>Molecular and Cellular Biology >The Acetyltransferase Activity of CBP Is Required for wingless Activation and H4 Acetylation in Drosophila melanogaster
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The Acetyltransferase Activity of CBP Is Required for wingless Activation and H4 Acetylation in Drosophila melanogaster

机译：果蝇的无翅活化和H4乙酰化需要CBP的乙酰基转移酶活性。

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CBP is a critical coactivator of transcription, but little is understood about the importance of its intrinsic acetyltransferase (AT) activity in gene activation in vivo. We show that the intrinsic AT function of CBP in Drosophila melanogaster (dCBP) is necessary to maintain a dCBP overexpression phenotype in the eye, for the in vivo activation of a specific target gene, wingless, and for the global acetylation of histone H4. These findings indicate that a point mutation which alters the intrinsic AT activity of CBP (only one of many CBP functions) has profound effects on CBP-induced gene activation in a physiologically intact transcription system. Furthermore, the effects of CBP AT activity are not limited to a few specific promoters, but rather CBT AT activity may play a role in regulating global histone acetylation throughout the developing organism.
机译：CBP是转录的关键共激活因子，但对其内在的乙酰基转移酶（AT）活性在体内基因激活中的重要性了解甚少。我们显示，果蝇（dCBP）中CBP的内在AT功能对于维持dCBP在眼睛中的过表达表型是必要的，以便在体内激活特定的靶基因 wingless < / em>，并用于组蛋白H4的整体乙酰化。这些发现表明，改变CBP固有AT活性的点突变（仅是许多CBP功能中的一种）对生理完整的转录系统中CBP诱导的基因激活具有深远的影响。此外，CBP AT活性的影响不仅限于少数特定的启动子，而是CBT AT活性可能在整个发育中的生物体中调节全局组蛋白乙酰化。

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