Disseminated Candidiasis and Hepatic Malarial Infection in Mannose-Binding-Lectin-A-Deficient Mice

Sena J. Lee; Gloria Gonzalez-Aseguinolaza; Michel C. Nussenzweig

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Disseminated Candidiasis and Hepatic Malarial Infection in Mannose-Binding-Lectin-A-Deficient Mice

机译：甘露糖结合凝集素A缺陷小鼠的传播念珠菌病和肝疟疾感染。

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To examine the physiological functions of mannose-binding lectin A (MBL-A), we generated mice that were deficient in MBL-A and examined their susceptibilities to the microbial pathogens Candida albicans and Plasmodium yoelii, an accepted experimental malaria model in mouse. We found no differences in the survival rates and fungal burdens of wild-type and MBL-A?/? mice with disseminated C. albicans infection. The two mouse strains were also similar in their abilities to resist hepatic accumulation of P. yoelii parasites. We conclude that MBL-A deficiency does not alter resistance to disseminated candidiasis or initial hepatic invasion by P. yoelii.

机译：为了检查甘露糖结合凝集素A（MBL-A）的生理功能，我们产生了MBL-A缺陷的小鼠，并检查了它们对微生物病原体白色念珠菌和约氏疟原虫的敏感性，一种公认的小鼠实验性疟疾模型。我们发现，野生型和散布 C的MBL-A ？/？小鼠的存活率和真菌负担没有差异。白色念珠菌感染。两种小鼠品系在抵抗 P肝积累方面的能力也相似。 yoelii 寄生虫。我们得出的结论是，MBL-A缺乏症不会改变对散发念珠菌病或 P最初入侵肝的抵抗力。 yoelii 。 展开▼

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《Molecular and Cellular Biology》 |2002年第23期|共5页

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Sena J. Lee; Gloria Gonzalez-Aseguinolaza; Michel C. Nussenzweig;
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中图分类细胞生物学;

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1. A Competitive Infection Model of Hematogenously Disseminated Candidiasis in Mice Redefines the Role of Candida albicans IRS4 in Pathogenesis [J] . Suresh B. Raman, M. Hong Nguyen, Shaoji Cheng, Infection and immunity . 2013,第5期

机译：小鼠血行传播念珠菌病的竞争性感染模型重新定义了白色念珠菌IRS4在发病机理中的作用。

2. Immunosuppressive Effect of Disseminated Breast Carcinoma on Severity of Hepatic Candidiasis [J] . S. Chakravarthi, C.Z. Wei, H.S. Nagaraja, Research Journal of Immunology . 2010,第1期

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6. Disseminated Candidiasis and Hepatic Malarial Infection in Mannose-Binding-Lectin-A-Deficient Mice [O] . Sena J. Lee, Gloria Gonzalez-Aseguinolaza, Michel C. Nussenzweig 2002

机译：甘露糖结合凝集素A缺陷小鼠的传播念珠菌病和肝疟疾感染。

7. Disseminated Candidiasis and Hepatic Malarial Infection in Mannose-Binding-Lectin-A-Deficient Mice [O] . Lee, Sena J., Gonzalez-Aseguinolaza, Gloria, Nussenzweig, Michel C. 2002

机译：甘露糖结合凝集素A缺陷小鼠的传播念珠菌病和肝疟疾感染。

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Disseminated Candidiasis and Hepatic Malarial Infection in Mannose-Binding-Lectin-A-Deficient Mice

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