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首页> 外文期刊>Molecular and Cellular Biology >Asp1, a Conserved 1/3 Inositol Polyphosphate Kinase, Regulates the Dimorphic Switch in Schizosaccharomyces pombe
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Asp1, a Conserved 1/3 Inositol Polyphosphate Kinase, Regulates the Dimorphic Switch in Schizosaccharomyces pombe

机译：Asp1，保守的1/3肌醇多磷酸激酶，调节裂殖酵母中的双态开关。

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摘要

The ability to undergo dramatic morphological changes in response to extrinsic cues is conserved in fungi. We have used the model yeast Schizosaccharomyces pombe to determine which intracellular signal regulates the dimorphic switch from the single-cell yeast form to the filamentous invasive growth form. The S. pombe Asp1 protein, a member of the conserved Vip1 1/3 inositol polyphosphate kinase family, is a key regulator of the morphological switch via the cAMP protein kinase A (PKA) pathway. Lack of a functional Asp1 kinase domain abolishes invasive growth which is monopolar, while an increase in Asp1-generated inositol pyrophosphates (PP) increases the cellular response. Remarkably, the Asp1 kinase activity encoded by the N-terminal part of the protein is regulated negatively by the C-terminal domain of Asp1, which has homology to acid histidine phosphatases. Thus, the fine tuning of the cellular response to environmental cues is modulated by the same protein. As the Saccharomyces cerevisiae Asp1 ortholog is also required for the dimorphic switch in this yeast, we propose that Vip1 family members have a general role in regulating fungal dimorphism.
机译：在真菌中，保留了响应于外部信号而发生剧烈的形态变化的能力。我们已经使用模型酵母 Schizosaccharomyces pombe 来确定哪种细胞内信号调节从单细胞酵母形式到丝状浸润生长形式的双态转换。 S。保守的Vip1 1/3肌醇多磷酸激酶家族成员pombe Asp1蛋白是通过cAMP蛋白激酶A（PKA）途径进行形态转换的关键调节剂。缺乏功能性Asp1激酶结构域可消除单极性侵袭性生长，而Asp1生成的肌醇焦磷酸盐（PP）的增加会增加细胞反应。值得注意的是，由蛋白质N末端部分编码的Asp1激酶活性受到与酸性组氨酸磷酸酶同源的Asp1的C末端域的负调控。因此，细胞对环境提示的反应的微调由相同的蛋白质调节。由于酿酒酵母 Asp1直向同源物也是该酵母的双态转换所必需的，因此我们建议Vip1家族成员在调节真菌双态中起一般作用。

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