• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular and Cellular Biology >SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription.
【24h】

SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription.

机译：SOK2可能通过抑制转录调节环AMP依赖性蛋白激酶刺激的生长和假菌丝发育。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Yeast cyclic AMP (cAMP)-dependent protein kinase (PKA) activity is essential for growth and cell cycle progression. Dependence on PKA function can be partially relieved by overexpression of a gene, SOK2, whose product has significant homology with several fungal transcription factors (StuA from Aspergillus nidulans and Phd1 from Saccharomyces cerevisiae) that are associated with cellular differentiation and development. Deletion of SOK2 is not lethal but exacerbates the growth defect of strains compromised for PKA activity. Alterations in Sok2 protein production also affect the expression of genes involved in several other PKA-regulated processes, including glycogen accumulation (GAC1) and heat shock resistance (SSA3). These results suggest SOK2 plays a general regulatory role in the PKA signal transduction pathway. Expression of the PKA catalytic subunit genes is unaltered by deletion or overexpression of SOK2. Because homozygous sok2/sok2 diploid strains form pseudohyphae at an accelerated rate, the Sok2 protein may inhibit the switch from unicellular to filamentous growth, a process that is dependent on cAMP. Thus, the product of SOK2 may act downstream of PKA to regulate the expression of genes important in growth and development.
机译：酵母环AMP（cAMP）依赖性蛋白激酶（PKA）活性对于生长和细胞周期进程至关重要。对PKA功能的依赖性可以通过基因SOK2的过表达而部分缓解，该基因的表达与几种与细胞分化和发育相关的真菌转录因子（来自构巢曲霉的StuA和来自酿酒酵母的Phd1）具有显着的同源性。 SOK2的删除不是致命的，但是加剧了因PKA活性受损的菌株的生长缺陷。 Sok2蛋白产量的变化也影响其他几个PKA调控过程所涉及基因的表达，包括糖原积累（GAC1）和抗热休克（SSA3）。这些结果表明，SOK2在PKA信号转导途径中起一般调节作用。 PKA催化亚基基因的表达不会因SOK2的缺失或过表达而改变。由于纯合的sok2 / sok2二倍体菌株以加速的速率形成假菌丝，因此Sok2蛋白可能抑制了从单细胞向丝状生长的转换，这取决于cAMP。因此，SOK2的产物可在PKA的下游起作用以调节对生长和发育重要的基因的表达。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号