hSiah2 Is a New Vav Binding Protein Which Inhibits Vav-Mediated Signaling Pathways

Antonia Germani; Francisco Romero; Martin Houlard; Jacques Camonis; Sylvie Gisselbrecht; Siegmund Fischer; Nadine Varin-Blank

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hSiah2 Is a New Vav Binding Protein Which Inhibits Vav-Mediated Signaling Pathways

机译：hSiah2是一种新型的Vav结合蛋白，可抑制Vav介导的信号通路

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The hematopoietic proto-oncogene vav has been characterized as a Rac1-GDP/GTP exchanger protein which regulates cytoskeletal reorganization as well as signaling pathways leading to the activation of stress-activated protein kinases (SAPK/JNKs). Furthermore, vav overexpression enhances basal and T-cell receptor (TCR)-mediated stimulation of the nuclear factor of activated T cells (NFAT). We report here the interaction between Vav and hSiah2, a mammalian homolog of Drosophila Seven in absentia (Sina) that has been implicated in R7 photoreceptor cell formation during Drosophila eye development via the proteasome degradation pathway. Vav and hSiah2 interact in vitro and in vivo and colocalize in the cytoplasm of hematopoietic cells. The Src homology domain of Vav and the C-terminal region of hSiah2 are required for this interaction. We provide evidence for a negative regulation by hSiah2 of Vav-induced basal and TCR-mediated NFAT-dependent transcription. Overexpression of hSiah2 also inhibits the onco-Vav-induced JNK activation. Although the Vav-interacting domain is located in the C-terminal portion of hSiah2, the N-terminal region of hSiah2 is necessary for the inhibitory role that seems to be independent of the proteasome degradation.

机译：造血原癌基因 vav 已被表征为Rac1-GDP / GTP交换蛋白，可调节细胞骨架重组以及导致应激活化蛋白激酶（SAPK / JNKs）活化的信号通路。此外， vav 的过表达增强了活化T细胞核因子（NFAT）的基础和T细胞受体（TCR）介导的刺激。我们在这里报告Vav和hSiah2之间的相互作用，hSiah2是在果蝇（Sina）中的果蝇七的哺乳动物同系物，与通过果蝇的果蝇眼睛发育过程中的R7感光细胞形成有关。蛋白酶体降解途径。 Vav和hSiah2在体内和体外相互作用，并共定位于造血细胞的细胞质中。这种相互作用需要Vav的Src同源结构域和hSiah2的C端区域。我们提供了由hSiah2对Vav诱导的基础和TCR介导的NFAT依赖性转录的负调控的证据。 hSiah2的过表达也抑制了癌基因-Vav诱导的JNK激活。尽管Vav相互作用域位于hSiah2的C末端部分，但hSiah2的N末端区域对于似乎与蛋白酶体降解无关的抑制作用是必需的。 展开▼

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《Molecular and Cellular Biology》 |1999年第5期|共10页

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Antonia Germani; Francisco Romero; Martin Houlard; Jacques Camonis; Sylvie Gisselbrecht; Siegmund Fischer; Nadine Varin-Blank;
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中图分类细胞生物学;

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1. hSiah2 Is a New Vav Binding Protein Which Inhibits Vav-Mediated Signaling Pathways [J] . Antonia Germani, Francisco Romero, Martin Houlard, Molecular and Cellular Biology . 1999,第5期

机译：hSiah2是一种新型的Vav结合蛋白，可抑制Vav介导的信号通路

2. Apolipoprotein A-1 Binding Protein Inhibits Inflammatory Signaling Pathways by Binding to Apolipoprotein A-1 in THP-1 Macrophages [J] . Min Zhang, Guo-Jun Zhao, Kai Yin, Circulation journal . 2018,第5期

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3. Apolipoprotein A-1 Binding Protein Inhibits Inflammatory Signaling Pathways by Binding to Apolipoprotein A-1 in THP-1 Macrophages [J] . Zhang Min, Zhao Guo-Jun, Yin Kai, Circulation journal . 2018,第5期

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6. hSiah2 Is a New Vav Binding Protein Which Inhibits Vav-Mediated Signaling Pathways [O] . Antonia Germani, Francisco Romero, Martin Houlard, 1999

机译：hSiah2是一种新型的Vav结合蛋白可抑制Vav介导的信号通路

7. hSiah2 Is a New Vav Binding Protein Which Inhibits Vav-Mediated Signaling Pathways [O] . Germani, Antonia, Romero, Francisco, Houlard, Martin, 1999

机译：hSiah2是一种新型的Vav结合蛋白，可抑制Vav介导的信号通路

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hSiah2 Is a New Vav Binding Protein Which Inhibits Vav-Mediated Signaling Pathways

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