Nuclear localization and cell cycle regulation of a murine protein tyrosine phosphatase.

U Tillmann; J Wagner; D Boerboom; H Westphal; M L Tremblay

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Nuclear localization and cell cycle regulation of a murine protein tyrosine phosphatase.

机译：鼠蛋白酪氨酸磷酸酶的核定位和细胞周期调控。

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MPTP is a murine homolog of the human T-cell protein tyrosine phosphatase (PTPase) and the rat PTP-S enzyme. Enzymatic activity of this ubiquitously expressed protein was demonstrated in immunoprecipitates from NIH 3T3 cells and in recombinant protein overexpressed in bacteria. Expression of beta-galactosidase-MPTP MPTP chimeric proteins in COS1 cells identified a nuclear localization signal at the carboxyl terminus of the MPTP that was sufficient to direct beta-galactosidase as well as a tagged version of the MPTP to the nucleus. Deletion analysis of amino acids within the nuclear targeting signal showed that this sequence does not conform to the bipartite type of nuclear localization signals. Furthermore, it was shown that the steady-state levels of MPTP RNA fluctuate in a cell cycle-specific manner. On the basis of these experiments, we discuss the possible function of MPTP in the cell cycle and other nuclear processes.

机译：MPTP是人T细胞蛋白酪氨酸磷酸酶（PTPase）和大鼠PTP-S酶的鼠类同源物。在NIH 3T3细胞的免疫沉淀物中和在细菌中过表达的重组蛋白中都证明了这种普遍表达的蛋白的酶活性。 β-半乳糖苷酶-MPTP MPTP嵌合蛋白在COS1细胞中的表达确定了在MPTP羧基末端的核定位信号，该信号足以将β-半乳糖苷酶以及MPTP的标记版本导向细胞核。核靶向信号中氨基酸的缺失分析表明，该序列与核定位信号的二分型不符。此外，已经表明，MPTP RNA的稳态水平以细胞周期特异性方式波动。在这些实验的基础上，我们讨论了MPTP在细胞周期和其他核过程中的可能功能。

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《Molecular and Cellular Biology》 |1994年第5期|共11页
作者
U Tillmann; J Wagner; D Boerboom; H Westphal; M L Tremblay;
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中图分类细胞生物学;
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6. Nuclear localization and cell cycle regulation of a murine protein tyrosine phosphatase. [O] . U Tillmann, J Wagner, D Boerboom, 1994

机译：鼠蛋白酪氨酸磷酸酶的核定位和细胞周期调控。
7. Nuclear localization and cell cycle regulation of a murine protein tyrosine phosphatase. [O] . Tillmann, U, Wagner, J, Boerboom, D, 1994

机译：鼠蛋白酪氨酸磷酸酶的核定位和细胞周期调控。
8. Activation of Tyrosine Phosphorylation in Human T Cells via the CD2 Pathway: Regulation by the CD45 Tyrosine phosphatase. [R] . Samelson, L., Fletcher, M. C., Ledbetter, J. A., 1990

机译：通过CD2途径激活人T细胞中的酪氨酸磷酸化：CD45酪氨酸磷酸酶的调节。

Nuclear localization and cell cycle regulation of a murine protein tyrosine phosphatase.

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