Signal-induced degradation of I(kappa)B(alpha): association with NF-kappaB and the PEST sequence in I(kappa)B(alpha) are not required.

D J Van Antwerp; I M Verma

首页> 外文期刊>Molecular and Cellular Biology >Signal-induced degradation of I(kappa)B(alpha): association with NF-kappaB and the PEST sequence in I(kappa)B(alpha) are not required.

【24h】

Signal-induced degradation of I(kappa)B(alpha): association with NF-kappaB and the PEST sequence in I(kappa)B(alpha) are not required.

机译：信号诱导的IκBα降解：不需要与NFκB和IκBα中的PEST序列相关联。

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Signal-induced degradation of I(kappa)B(alpha) via the ubiquitin-proteasome pathway requires phosphorylation on residues serine 32 and serine 36 followed by ubiquitination on lysines 21 and 22. We investigated the role of other regions of I(kappa)B(alpha) which may be involved in its degradation. Here we report that the carboxy-terminal PEST sequence is not required for I(kappa)B(alpha) signal-induced degradation. However, removal of the PEST sequence stabilizes free I(kappa)B(alpha) in unstimulated cells. We further report that a PEST deletion mutant does not associate well with NF-(kappa)B proteins but is degraded in response to signal. Therefore, we conclude that both association with NF-(kappa)B and a PEST sequence are not required for signal-induced I(kappa)B(alpha) degradation. Additionally, the PEST sequence may be required for constitutive turnover of free I(kappa)B(alpha).

机译：通过泛素-蛋白酶体途径信号诱导的I（kappa）Bα降解需要在丝氨酸32和丝氨酸36残基上进行磷酸化，然后在赖氨酸21和22上进行泛素化。我们研究了I（kappa）B其他区域的作用可能与其降解有关的α。在这里我们报告I（kB）Bα信号诱导的降解不需要羧基末端PEST序列。但是，去除PEST序列可稳定未刺激细胞中的游离IκBα。我们进一步报告，PEST缺失突变体与NF-（κ）B蛋白没有很好的关联，但响应信号而降解。因此，我们得出结论，信号诱导的IκBα降解不需要与NF-κB和PEST序列相关联。另外，游离I（κ）Bα的组成性更新可能需要PEST序列。

著录项

来源
《Molecular and Cellular Biology》 |1996年第11期|共9页
作者
D J Van Antwerp; I M Verma;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类细胞生物学;
关键词

相似文献

外文文献
中文文献
专利

1. Signal-induced degradation of I(kappa)B(alpha): association with NF-kappaB and the PEST sequence in I(kappa)B(alpha) are not required. [J] . D J Van Antwerp, I M Verma Molecular and Cellular Biology . 1996,第11期

机译：信号诱导的IκBα降解：不需要与NFκB和IκBα中的PEST序列相关联。
2. A mechanistic insight into a proteasome-independent constitutive inhibitor kappa B alpha (I kappa B alpha) degradation and nuclear factor kappa B (NF-kappa B) activation pathway in WEHI-231 B-cells [J] . Shumway SD, Miyamoto S The Biochemical Journal . 2004,第0期

机译：深入了解WEHI-231 B细胞中不依赖蛋白酶体的组成性抑制剂kappa B alpha（I kappa B alpha）降解和核因子kappa B（NF-kappa B）激活途径的机制
3. A mechanistic insight into a proteasome-independent constitutive inhibitor kappa B alpha (I kappa B alpha) degradation and nuclear factor kappa B (NF-kappa B) activation pathway in WEHI-231 B-cells [J] . Shumway SD, Miyamoto S The Biochemical Journal . 2004,第Pta1期

机译：深入了解WEHI-231 B细胞中不依赖蛋白酶体的组成性抑制剂kappa B alpha（I kappa B alpha）降解和核因子kappa B（NF-kappa B）激活途径的机制
4. Modeling Recharge Time of Radio Frequency Energy Harvesters in alpha-eta-µ and alpha-kappa-µ Fading Channels [C] . Ehab Salahat, Nan Yang IEEE International Conference on Communications Workshops . 2018

机译：在alpha-eta-µ和alpha-kappa-µ衰落通道中模拟射频能量收集器的充电时间
5. NMR studies of the transcriptional inhibitor I kappa B alpha and its interaction with the transcription factor NF kappa B. [D] . Cervantes, Carla F. 2010

机译：转录抑制剂IκB alpha及其与转录因子NFκB相互作用的NMR研究。
6. Signal-induced degradation of I(kappa)B(alpha): association with NF-kappaB and the PEST sequence in I(kappa)B(alpha) are not required. [O] . D J Van Antwerp, I M Verma 1996

机译：信号诱导的IκBα降解：不需要与NFκB和IκBα中的PEST序列相关联。
7. Signal-induced degradation of I(kappa)B(alpha): association with NF-kappaB and the PEST sequence in I(kappa)B(alpha) are not required. [O] . Van Antwerp, D J, Verma, I M 1996

机译：信号诱导的IκBα降解：不需要与NFκB和IκBα中的PEST序列相关联。
8. Study of Configuration Interactions of Atoms of Several Incomplete Electronic Layers. Application and Identification of kappa alpha Satellites in Light Atoms . Etude de Linteraction de Configurations Dans des Atomes a Plusieurs Couches Electroniques Incompletes. Application a Lidentification des Satellites kappa alpha Dans les Atomes Legers [R] . Sureau, A. 1970

机译：几个不完全电子层原子配置相互作用的研究。 Kappa alpha卫星在光原子中的应用与识别。 Etude de Linteraction de Configurations Dans des atomes a plusieurs Couches Electroniques Incompletes。应用Lidentification des satellites kappa alpha Dans les atomes Legers

Signal-induced degradation of I(kappa)B(alpha): association with NF-kappaB and the PEST sequence in I(kappa)B(alpha) are not required.

摘要

著录项

相似文献

相关主题

期刊订阅