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首页> 外文期刊>Molecular and Cellular Biology >MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression
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MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression

机译：miR-106b家族中的MicroRNA调节p21 / CDKN1A并促进细胞周期进程

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microRNAs in the miR-106b family are overexpressed in multiple tumor types and are correlated with the expression of genes that regulate the cell cycle. Consistent with these observations, miR-106b family gain of function promotes cell cycle progression, whereas loss of function reverses this phenotype. Microarray profiling uncovers multiple targets of the family, including the cyclin-dependent kinase inhibitor p21/CDKN1A. We show that p21 is a direct target of miR-106b and that its silencing plays a key role in miR-106b-induced cell cycle phenotypes. We also show that miR-106b overrides a doxorubicin-induced DNA damage checkpoint. Thus, miR-106b family members contribute to tumor cell proliferation in part by regulating cell cycle progression and by modulating checkpoint functions.
机译：miR-106b家族中的microRNA在多种肿瘤类型中过表达，并且与调节细胞周期的基因表达相关。与这些观察结果一致，miR-106b家族功能获得促进细胞周期进程，而功能丧失则逆转该表型。微阵列分析揭示了该家族的多个靶标，包括细胞周期蛋白依赖性激酶抑制剂p21 / CDKN1A。我们显示p21是miR-106b的直接靶标，并且其沉默在miR-106b诱导的细胞周期表型中起关键作用。我们还显示，miR-106b替代了阿霉素诱导的DNA损伤检查点。因此，miR-106b家族成员部分通过调节细胞周期进程和调节检查点功能来促进肿瘤细胞增殖。

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