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首页> 外文期刊>Molecular and Cellular Biology >Male Infertility, Impaired Sperm Motility, and Hydrocephalus in Mice Deficient in Sperm-Associated Antigen 6
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Male Infertility, Impaired Sperm Motility, and Hydrocephalus in Mice Deficient in Sperm-Associated Antigen 6

机译：精子相关抗原缺乏的小鼠的男性不育，精子活动能力受损和脑积水6

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Gene targeting was used to create mice lacking sperm-associated antigen 6 (Spag6), the murine orthologue of Chlamydomonas PF16, an axonemal protein containing eight armadillo repeats predicted to be important for flagellar motility and stability of the axoneme central apparatus. Within 8 weeks of birth, approximately 50% of Spag6-deficient animals died with hydrocephalus. Spag6-deficient males surviving to maturity were infertile. Their sperm had marked motility defects and was morphologically abnormal with frequent loss of the sperm head and disorganization of flagellar structures, including loss of the central pair of microtubules and disorganization of the outer dense fibers and fibrous sheath. We conclude that Spag6 is essential for sperm flagellar motility and that it is important for the maintenance of the structural integrity of mature sperm. The occurrence of hydrocephalus in the mutant mice also implicates Spag6 in the motility of ependymal cilia.
机译：基因靶向技术可用于产生缺乏精子相关抗原6（Spag6）的小鼠，而精子相关抗原是衣藻PF16的鼠直向同源物，该蛋白是含有八个犰狳重复序列的轴突蛋白，预计对鞭毛运动和轴突稳定性很重要。中央设备。出生后8周内，约有50％患有Spag6缺陷的动物死于脑积水。存活到Spag6缺陷的雄性不育。它们的精子具有明显的运动缺陷，形态上异常，精子头经常丢失，鞭毛结构紊乱，包括中央微管对丢失，外部致密纤维和纤维鞘紊乱。我们得出结论，Spag6对于精子鞭毛运动是必不可少的，并且对于维持成熟精子的结构完整性很重要。在突变小鼠中脑积水的发生也暗示Spag6参与室管膜纤毛的运动。

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