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首页> 外文期刊>Molecular and Cellular Biology >Defective Dendrite Elongation but Normal Fertility in Mice Lacking the Rho-Like GTPase Activator Dbl
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Defective Dendrite Elongation but Normal Fertility in Mice Lacking the Rho-Like GTPase Activator Dbl

机译：缺乏Rho样GTPase激活因子Dbl的小鼠中的枝晶缺陷伸长率正常，但生育能力正常

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摘要

Dbl is the prototype of a large family of GDP-GTP exchange factors for small GTPases of the Rho family. In vitro, Dbl is known to activate Rho and Cdc42 and to induce a transformed phenotype. Dbl is specifically expressed in brain and gonads, but its in vivo functions are largely unknown. To assess its role in neurogenesis and gametogenesis, targeted deletion of the murine Dbl gene was accomplished in embryonic stem cells. Dbl-null mice are viable and did not show either decreased reproductive performances or obvious neurological defects. Histological analysis of mutant testis showed normal morphology and unaltered proliferation and survival of spermatogonia. Dbl-null brains indicated a correct disposition of the major neural structures. Analysis of cortical stratification indicated that Dbl is not crucial for neuronal migration. However, in distinct populations of Dbl-null cortical pyramidal neurons, the length of dendrites was significantly reduced, suggesting a role for Dbl in dendrite elongation.
机译：Dbl是Rho家族的小GTPase的GDP-GTP交换因子大家族的原型。在体外，已知Dbl激活Rho和Cdc42并诱导转化的表型。 Dbl在脑和性腺中特异性表达，但其体内功能很大程度上未知。为了评估其在神经发生和配子发生中的作用，在胚胎干细胞中实现了小鼠 Dbl 基因的靶向缺失。 Dbl -无效的小鼠是有活力的，并且既没有表现出生殖能力下降，也没有表现出明显的神经系统缺陷。突变睾丸的组织学分析显示精子形态正常，精原细胞的增殖和存活没有改变。 Dbl -无效的大脑表明主要神经结构的正确配置。皮质分层的分析表明，Dbl对神经元迁移并不关键。然而，在 Dbl -无皮质锥体神经元的不同群体中，树突的长度显着减少，表明Dbl在树突延长中发挥作用。

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