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首页> 外文期刊>Molecular and Cellular Biology >Stat1 and Stat2 but Not Stat3 Arbitrate Contradictory Growth Signals Elicited by Alpha/Beta Interferon in T Lymphocytes
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Stat1 and Stat2 but Not Stat3 Arbitrate Contradictory Growth Signals Elicited by Alpha/Beta Interferon in T Lymphocytes

机译：Stat1和Stat2，但不是Stat3仲裁性矛盾的增长信号，由T细胞中的α/β干扰素引起。

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Alpha/beta interferon (IFN-α/β) triggers antiviral and antiproliferative responses in target cells through modulation of gene expression. The JAK-STAT pathway is the major mediator of these biological effects through the activation of the transcription factors STAT1 and STAT2, and gene ablation studies have demonstrated that both STAT1 and STAT2 are required for most antiviral responses induced by IFN-α/β. However, additional signaling pathways are also activated by IFN. Here, we show that these additional pathways provoke a proliferative response in activated T lymphocytes. While activation of IFN-stimulated gene factor 3 produces a dominant inhibitory signal capable of overriding the mitogenic response, absence of either STAT1 or STAT2 leads to a proliferative response to IFN. Growth stimulation by IFN-α/β is independent of other STAT proteins, particularly of STAT3, since T lymphocytes from STAT1-STAT3 double-knockout mice are growth stimulated by IFN-α/β treatment. IFN-α/β can cooperate with numerous T-cell mitogens, including interleukin-2 (IL-2), IL-4, IL-7, and IL-12, and can contribute to the rapid restoration of the thymus following glucocorticoid-mediated ablation. These results underscore the complexity of the cellular response to IFN and suggest that the ultimate outcome of IFN action results from a balance between growth-inhibitory and -stimulatory effects.
机译：α/β干扰素（IFN-α/β）通过调节基因表达在靶细胞中触发抗病毒和抗增殖反应。 JAK-STAT途径是通过激活转录因子STAT1和STAT2来介导这些生物学效应的主要介质，并且基因消融研究表明IFN-α/β诱导的大多数抗病毒应答均需要STAT1和STAT2。但是，其他信号传导途径也被IFN激活。在这里，我们显示这些额外的途径在活化的T淋巴细胞中引起增殖反应。尽管IFN刺激的基因因子3的激活产生了能够抑制有丝分裂反应的显性抑制信号，但STAT1或STAT2的缺失都会导致对IFN的增殖反应。 IFN-α/β的生长刺激独立于其他STAT蛋白，尤其是STAT3，因为来自STAT1-STAT3双敲除小鼠的T淋巴细胞受到IFN-α/β处理的生长刺激。 IFN-α/β可以与许多T细胞促分裂原协同工作，包括白介素2（IL-2），IL-4，IL-7和IL-12，并有助于糖皮质激素-后胸腺的快速恢复。介导的消融。这些结果强调了细胞对IFN的反应的复杂性，并表明IFN作用的最终结果来自生长抑制作用和刺激作用之间的平衡。

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