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首页> 外文期刊>Molecular and Cellular Biology >Photic Signaling by Cryptochrome in the DrosophilaCircadian System
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Photic Signaling by Cryptochrome in the DrosophilaCircadian System

机译：果蝇昼夜节律系统中隐色的光信号传导

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摘要

Oscillations of the period (per) andtimeless (tim) gene products are an integral part of the feedback loop that underlies circadian behavioral rhythms in Drosophila melanogaster. Resetting this loop in response to light requires the putative circadian photoreceptor cryptochrome (CRY). We dissected the early events in photic resetting by determining the mechanisms underlying the CRY response to light and by investigating the relationship between CRY and the light-induced ubiquitination of the TIM protein. In response to light, CRY is degraded by the proteasome through a mechanism that requires electron transport. Various CRY mutant proteins are not degraded, and this suggests that an intramolecular conversion is required for this light response. Light-induced TIM ubiquitination precedes CRY degradation and is increased when electron transport is blocked. Thus, inhibition of electron transport may “lock” CRY in an active state by preventing signaling required either to degrade CRY or to convert it to an inactive form. High levels of CRY block TIM ubiquitination, suggesting a mechanism by which light-driven changes in CRY could control TIM ubiquitination.
机译：期间（ per ）和永恒（ tim ）基因产物的振荡是反馈回路的组成部分是果蝇果蝇的昼夜节律行为的基础。为了响应光线而重置此环路，需要假定的昼夜节律感光体隐色体（CRY）。我们通过确定CRY对光反应的基础机制并研究CRY与TIM蛋白的光诱导泛素化之间的关系，剖析了光复性中的早期事件。响应光，CRY被蛋白酶体通过需要电子传输的机制降解。各种CRY突变蛋白不会降解，这表明这种光响应需要分子内转化。光诱导的TIM泛素化先于CRY降解，并在电子传输受阻时增加。因此，通过防止降解CRY或将其转化为非活性形式所需的信号传递，抑制电子传输可将CRY“锁定”在活性状态。高水平的CRY阻止TIM泛素化，这表明光驱动CRY变化可以控制TIM泛素化的机制。

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