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首页> 外文期刊>Molecular and Cellular Biology >The DEK Nuclear Autoantigen Is a Secreted Chemotactic Factor
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The DEK Nuclear Autoantigen Is a Secreted Chemotactic Factor

机译：DEK核自身抗原是一种分泌的趋化因子。

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The nuclear DNA-binding protein DEK is an autoantigen that has been implicated in the regulation of transcription, chromatin architecture, and mRNA processing. We demonstrate here that DEK is actively secreted by macrophages and is also found in synovial fluid samples from patients with juvenile arthritis. Secretion of DEK is modulated by casein kinase 2, stimulated by interleukin-8, and inhibited by dexamethasone and cyclosporine A, consistent with a role as a proinflammatory molecule. DEK is secreted in both a free form and in exosomes, vesicular structures in which transcription-modulating factors such as DEK have not previously been found. Furthermore, DEK functions as a chemotactic factor, attracting neutrophils, CD8+ T lymphocytes, and natural killer cells. Therefore, the DEK autoantigen, previously described as a strictly nuclear protein, is secreted and can act as an extracellular chemoattractant, suggesting a direct role for DEK in inflammation.
机译：核DNA结合蛋白DEK是一种自身抗原，与转录，染色质结构和mRNA加工的调控有关。我们在这里证明了巨噬细胞活跃地分泌DEK，并且在青少年关节炎患者的滑液样本中也发现了DEK。 DEK的分泌受酪蛋白激酶2调节，酪蛋白激酶2受白介素8刺激，并被地塞米松和环孢霉素A抑制，与促炎分子的作用一致。 DEK以游离形式和外泌体（以前未发现转录调节因子，如DEK）的囊泡结构分泌。此外，DEK作为趋化因子起作用，吸引中性粒细胞，CD8 + T淋巴细胞和自然杀伤细胞。因此，以前被描述为严格的核蛋白的DEK自身抗原被分泌出来并可以作为细胞外趋化因子，提示DEK在炎症中具有直接作用。

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