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A MicroRNA Signature of Hypoxia

机译：低氧的MicroRNA特征

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Recent research has identified critical roles for microRNAs in a large number of cellular processes, including tumorigenic transformation. While significant progress has been made towards understanding the mechanisms of gene regulation by microRNAs, much less is known about factors affecting the expression of these noncoding transcripts. Here, we demonstrate for the first time a functional link between hypoxia, a well-documented tumor microenvironment factor, and microRNA expression. Microarray-based expression profiles revealed that a specific spectrum of microRNAs (including miR-23, -24, -26, -27, -103, -107, -181, -210, and -213) is induced in response to low oxygen, at least some via a hypoxia-inducible-factor-dependent mechanism. Select members of this group (miR-26, -107, and -210) decrease proapoptotic signaling in a hypoxic environment, suggesting an impact of these transcripts on tumor formation. Interestingly, the vast majority of hypoxia-induced microRNAs are also overexpressed in a variety of human tumors.
机译：最近的研究已经确定了microRNA在许多细胞过程中的关键作用，包括致瘤转化。尽管在了解微RNA调控基因的机制方面已经取得了重大进展，但对于影响这些非编码转录本表达的因素知之甚少。在这里，我们首次展示了缺氧，一个有据可查的肿瘤微环境因子和microRNA表达之间的功能联系。基于微阵列的表达谱揭示了对低氧的反应诱导了特定范围的microRNA谱（包括miR-23，-24，-26，-27，-103，-107，-181，-210和-213） ，至少某些是通过缺氧诱导因子依赖性机制引起的。该组中的特定成员（miR-26，-107和-210）在低氧环境中降低促凋亡信号传导，提示这些转录本对肿瘤形成有影响。有趣的是，大多数缺氧诱导的microRNA在多种人类肿瘤中也过表达。

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