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首页> 外文期刊>Molecular and Cellular Biology >The Rho Guanine Nucleotide Exchange Factor Syx Regulates the Balance of Dia and ROCK Activities To Promote Polarized-Cancer-Cell Migration
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The Rho Guanine Nucleotide Exchange Factor Syx Regulates the Balance of Dia and ROCK Activities To Promote Polarized-Cancer-Cell Migration

机译：Rho鸟嘌呤核苷酸交换因子Syx调节Dia和ROCK活性的平衡，促进极化的癌细胞迁移

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The role of RhoA in promoting directed cell migration has been complicated by studies showing that it is activated both in the front and the rear of migrating cells. We report here that the RhoA-specific guanine nucleotide exchange factor Syx is required for the polarity of actively migrating brain and breast tumor cells. This function of Syx is mediated by the selective activation of the RhoA downstream effector Dia1, the subsequent reorganization of microtubules, and the downregulation of focal adhesions and actin stress fibers. The data argue that directed cell migration requires the precise spatiotemporal regulation of Dia1 and ROCK activities in the cell. The recruitment of Syx to the cell membrane and the subsequent selective activation of Dia1 signaling, coupled with the suppression of ROCK and activation of cofilin-mediated actin reorganization, plays a key role in establishing cell polarity during directed cell migration.
机译：RhoA在促进定向细胞迁移中的作用由于研究表明其在迁移细胞的前部和后部均被激活而变得复杂。我们在这里报告，RhoA特异性鸟嘌呤核苷酸交换因子Syx是积极迁移大脑和乳腺肿瘤细胞的极性所必需的。 Syx的这种功能是由RhoA下游效应子Dia1的选择性激活，随后的微管重组以及粘着斑和肌动蛋白应激纤维的下调介导的。数据表明定向细胞迁移需要细胞中Dia1和ROCK活性的精确时空调节。 Syx募集到细胞膜和随后的Dia1信号选择性激活，再加上ROCK的抑制和cofilin介导的肌动蛋白重组的激活，在定向细胞迁移过程中建立细胞极性中起着关键作用。

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