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首页> 外文期刊>Molecular and Cellular Biology >Thioredoxin Regulates Multiple Hydrogen Peroxide-Induced Signaling Pathways in Candida albicans
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Thioredoxin Regulates Multiple Hydrogen Peroxide-Induced Signaling Pathways in Candida albicans

机译：硫氧还蛋白调节白色念珠菌中多个过氧化氢诱导的信号通路。

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The ability of the major systemic fungal pathogen of humans, Candida albicans, to sense and respond to reactive oxygen species (ROS), such as H2O2 generated by the host immune system, is required for survival in the host. However, the intracellular signaling mechanisms underlying such responses are poorly understood. Here, we show that thioredoxin (Trx1), in addition to its antioxidant activity, plays a central role in coordinating the response of C. albicans to ROS by regulating multiple pathways. In particular, Trx1 function is important for H2O2-induced phosphorylation of the Hog1 stress-activated protein kinase and to reverse H2O2-induced oxidation and activation of the AP-1 like transcription factor Cap1. Furthermore, Trx1 regulates H2O2-induced hyperpolarized bud growth in a mechanism that involves activation of the Rad53 checkpoint kinase. Consistent with its key roles in responses to ROS, cells lacking Trx1 displayed significantly attenuated virulence in a murine model of C. albicans systemic infection. Collectively, our data indicate that Trx1 has a multifaceted role in H2O2 signaling and promotes C. albicans survival in the host.
机译：人类主要的系统性真菌病原体白色念珠菌对H 2 O 2 <宿主免疫系统产生的/ sub>是宿主体内生存所必需的。但是，了解这种反应的细胞内信号传导机制知之甚少。在这里，我们显示了硫氧还蛋白（Trx1），除了其抗氧化活性外，在协调 C的响应中也起着核心作用。通过调节多种途径使白念珠转化为ROS。尤其是，Trx1功能对于H 2 O 2 诱导的Hog1应力激活蛋白激酶的磷酸化以及逆转H 2 O至关重要 2 诱导AP-1样转录因子Cap1的氧化和活化。此外，Trx1调节H 2 O 2 诱导的超极化芽生长，其机制涉及Rad53检查点激酶的激活。与其在对ROS的反应中起关键作用相一致，缺乏Trx1的细胞在 C鼠模型中显示出显着的减毒力。白色念珠菌全身感染。总体而言，我们的数据表明Trx1在H 2 O 2 信号传导中具有多方面的作用，并促进 C。宿主的白色念珠菌存活。

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