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Functional Analysis of Asb-1 Using Genetic Modification in Mice

机译：遗传修饰小鼠Asb-1的功能分析

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The Asbs are a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif, which was first identified in the suppressor of cytokine signaling (SOCS) proteins. While it is clear that the SOCS proteins are involved in the negative regulation of cytokine signaling, the biological roles of the other SOCS box-containing families are unknown. We have investigated Asb-1 function by generating mice that lack this protein, as well as mice that overexpress full-length or truncated Asb-1 in a wide range of tissues. Although Asb-1 is expressed in multiple organs, including the hematopoietic compartment in wild-type mice, Asb-1?/?mice develop normally and exhibit no anomalies of mature blood cells or their progenitors. While most organs in these mice appear normal, the testes of Asb-1?/? mice display a diminution of spermatogenesis with less complete filling of seminiferous tubules. In contrast, the widespread overexpression of Asb-1 in the mouse has no apparent deleterious effects.
机译：Asbs是锚蛋白重复蛋白家族，与其他四个蛋白家族一样，都包含一个C端SOCS盒基序，该基序首先在细胞因子信号转导（SOCS）蛋白的抑制剂中鉴定出来。虽然很明显，SOCS蛋白参与细胞因子信号传导的负调控，但其他包含SOCS盒的家族的生物学作用尚不清楚。我们已经通过产生缺乏这种蛋白质的小鼠以及在各种组织中过表达全长或截短的Asb-1的小鼠来研究Asb-1的功能。尽管Asb-1在野生型小鼠的包括造血区在内的多个器官中都有表达，但Asb-1 α/β小鼠的发育正常，没有成熟血细胞或其祖细胞的异常。尽管这些小鼠的大多数器官都显示正常，但Asb-1 α/β小鼠的睾丸显示出精子发生减少，而生精小管的填充不完全。相反，在小鼠中广泛表达的Asb-1没有明显的有害作用。

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