Normal Immune System Development in Mice Lacking the Deltex-1 RING Finger Domain

Sébastien Storck; Frédéric Delbos; Nicolas Stadler; Catherine Thirion-Delalande; Florence Bernex; Christophe Verthuy; Pierre Ferrier; Jean-Claude Weill; Claude-Agnès Reynaud

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Normal Immune System Development in Mice Lacking the Deltex-1 RING Finger Domain

机译：缺乏Deltex-1 RING指域的小鼠的正常免疫系统发育。

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The Notch signaling pathway controls several cell fate decisions during lymphocyte development, from T-cell lineage commitment to the peripheral differentiation of B and T lymphocytes. Deltex-1 is a RING finger ubiquitin ligase which is conserved from Drosophila to humans and has been proposed to be a regulator of Notch signaling. Its pattern of lymphoid expression as well as gain-of-function experiments suggest that Deltex-1 regulates both B-cell lineage and splenic marginal-zone B-cell commitment. Deltex-1 was also found to be highly expressed in germinal-center B cells. To investigate the physiological function of Deltex-1, we generated a mouse strain lacking the Deltex-1 RING finger domain, which is essential for its ubiquitin ligase activity. Deltex-1Δ/Δ mice were viable and fertile. A detailed histological analysis did not reveal any defects in major organs. T- and B-cell development was normal, as were humoral responses against T-dependent and T-independent antigens. These data indicate that the Deltex-1 ubiquitin ligase activity is dispensable for mouse development and immune function. Possible compensatory mechanisms, in particular those from a fourth Deltex gene identified during the course of this study, are also discussed.

机译：Notch信号通路控制着淋巴细胞发育过程中的几种细胞命运决定，从T细胞谱系承诺到B和T淋巴细胞的外周分化。 Deltex-1是一种RING手指泛素连接酶，从果蝇到人都是保守的，已被提议作为Notch信号的调节剂。它的淋巴样表达模式以及功能获得实验表明，Deltex-1调节B细胞谱系和脾边缘区B细胞定型。还发现 Deltex-1 在生发中心B细胞中高表达。为了研究Deltex-1的生理功能，我们生成了一个缺少Deltex-1 RING手指域的小鼠品系，该菌株对其泛素连接酶活性至关重要。 Deltex-1 Δ/Δ小鼠存活且能育。详细的组织学分析未发现主要器官有任何缺陷。 T细胞和B细胞发育正常，针对T依赖性和T依赖性抗原的体液反应也正常。这些数据表明，Deltex-1泛素连接酶活性对于小鼠发育和免疫功能是必不可少的。还讨论了可能的补偿机制，特别是在研究过程中鉴定出的第四个Deltex基因的补偿机制。 展开▼

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《Molecular and Cellular Biology》 |2005年第4期|共9页

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Sébastien Storck; Frédéric Delbos; Nicolas Stadler; Catherine Thirion-Delalande; Florence Bernex; Christophe Verthuy; Pierre Ferrier; Jean-Claude Weill; Claude-Agnès Reynaud;
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中图分类细胞生物学;

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7. Normal immune system development in mice lacking the Deltex-1 RING finger domain. [O] . Storck Sébastien, Delbos Frédéric, Stadler Nicolas, 2005

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Normal Immune System Development in Mice Lacking the Deltex-1 RING Finger Domain

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