...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular and Cellular Biology >mTOR-Independent Translational Control of the Extrinsic Cell Death Pathway by RalA
【24h】

mTOR-Independent Translational Control of the Extrinsic Cell Death Pathway by RalA

机译：RalA独立于mTOR的外源细胞死亡途径的翻译控制

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Oncogenic potential is associated with translational regulation, and the prevailing view is that oncogenes use mTOR-dependent pathways to up-regulate the synthesis of proteins critical for transformation. In this study, we show that RalA, a key mediator of Ras transformation, is also linked to the translational machinery. At least part of this linkage, however, is independent of mTOR and acts through RalBP1 to suppress cdc42-mediated activation of S6 kinase and the translation of the antiapoptotic protein FLIPS. This action, rather than contributing to transformation, opens a latent tumor-suppressive mechanism that can be activated by tumor necrosis factor-related apoptosis-inducing ligand. These results show that the translational machinery is linked to tumor suppression as well as cell-proliferative pathways and that the reestablishment of cell death pathways by activation of the Ral oncogenic program provides a means for selective therapeutic targeting of Ral-driven malignancies.
机译：致癌潜能与翻译调控相关，普遍的看法是癌基因使用mTOR依赖性途径上调对转化至关重要的蛋白质的合成。在这项研究中，我们表明RalA是Ras转化的关键介体，也与翻译机制有关。但是，这种连接的至少一部分独立于mTOR，并通过RalBP1发挥作用，以抑制cdc42介导的S6激酶激活和抗凋亡蛋白FLIP S 的翻译。该作用而不是促进转化，而开启了一种潜在的肿瘤抑制机制，该机制可以被肿瘤坏死因子相关的凋亡诱导配体激活。这些结果表明，翻译机制与肿瘤抑制以及细胞增殖途径相关，并且通过激活Ral致癌程序来重建细胞死亡途径为Ral驱动的恶性肿瘤的选择性治疗靶向提供了手段。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号