• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular and Cellular Biology >Requirement of the Tissue-Restricted Homeodomain Transcription Factor Nkx6.3 in Differentiation of Gastrin-Producing G Cells in the Stomach Antrum
【24h】

Requirement of the Tissue-Restricted Homeodomain Transcription Factor Nkx6.3 in Differentiation of Gastrin-Producing G Cells in the Stomach Antrum

机译：组织限制的同源域转录因子Nkx6.3在胃窦中产生胃泌素的G细胞分化中的要求。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Many homeodomain transcription factors function in organogenesis and cell differentiation. The Nkx family illustrates these functions especially well, and the Nkx6 subfamily controls differentiation in the central nervous system and pancreas. Nkx6.3, a recent addition to this subfamily, overlaps Nkx6.1 and Nkx6.2 in expression in the hindbrain and stomach. Nkx6.3 transcripts localize in the epithelium of the most distal stomach region, the antrum and pylorus; expression in the adult intestine is lower and confined to the proximal duodenum. Nkx6.3?/? mice develop and grow normally, with a grossly intact stomach and duodenum. These mice show markedly reduced gastrin mRNA, many fewer gastrin-producing (G) cells in the stomach antrum, hypogastrinemia, and increased stomach luminal pH, with a corresponding increase in somatostatin mRNA levels and antral somatostatin-producing (D) cells. They express normal levels of other transcription factors required for gastric endocrine cell differentiation, Pdx1, Pax6, and Ngn3; conversely, Ngn3?/? mice, which also show reduced gastrin levels, express Nkx6.3 normally. These studies implicate Nkx6.3 as a selective regulator of G- and D-cell lineages, which are believed to derive from a common progenitor, and suggest that it operates in parallel with Ngn3.
机译：许多同源域转录因子在器官发生和细胞分化中起作用。 Nkx 家族很好地说明了这些功能，而 Nkx6 子家族控制着中枢神经系统和胰腺的分化。 Nkx6.3 是该亚科的最新成员，在后脑和胃中的表达与 Nkx6.1 和 Nkx6.2 重叠。 Nkx6.3 转录本位于胃的最远端区域，胃窦和幽门的上皮中;在成人肠道中的表达较低，并局限于十二指肠近端。 Nkx6.3 ？ / ？小鼠的胃正常生长，并具有完整的胃和十二指肠。这些小鼠的胃泌素胃泌素 mRNA明显降低，胃窦中胃泌素生成（G）细胞少得多，胃泌素低血症，胃腔pH值升高，而胃抑素相应升高。 mRNA水平和胃窦生长抑素生成（D）细胞。它们表达胃内分泌细胞分化所需的其他转录因子，Pdx1，Pax6和Ngn3的正常水平。相反， Ngn3 ？ / ？小鼠也显示出降低的胃泌素水平，正常表达Nkx6.3。这些研究暗示Nkx6.3是G细胞和D细胞谱系的选择性调节因子，据信它们是来自共同祖细胞，并暗示其与Ngn3平行运行。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号