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首页> 外文期刊>Molecular and Cellular Biology >Extracellular Signal-Regulated Kinase Promotes Rho-Dependent Focal Adhesion Formation by Suppressing p190A RhoGAP
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Extracellular Signal-Regulated Kinase Promotes Rho-Dependent Focal Adhesion Formation by Suppressing p190A RhoGAP

机译：细胞外信号调节激酶通过抑制p190A RhoGAP促进Rho依赖的局灶性粘附形成。

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Cell migration is critical for normal development and for pathological processes including cancer cell metastasis. Dynamic remodeling of focal adhesions and the actin cytoskeleton are crucial determinants of cell motility. The Rho family and the mitogen-activated protein kinase (MAPK) module consisting of MEK-extracellular signal-regulated kinase (ERK) are important regulators of these processes, but mechanisms for the integration of these signals during spreading and motility are incompletely understood. Here we show that ERK activity is required for fibronectin-stimulated Rho-GTP loading, Rho-kinase function, and the maturation of focal adhesions in spreading cells. We identify p190A RhoGAP as a major target for ERK signaling in adhesion assembly and identify roles for ERK phosphorylation of the C terminus in p190A localization and activity. These observations reveal a novel role for ERK signaling in adhesion assembly in addition to its established role in adhesion disassembly.
机译：细胞迁移对于正常发育和包括癌细胞转移在内的病理过程至关重要。粘着斑和肌动蛋白细胞骨架的动态重塑是细胞运动的关键决定因素。 Rho家族和MEK-细胞外信号调节激酶（ERK）组成的促分裂原活化蛋白激酶（MAPK）模块是这些过程的重要调节剂，但在传播和运动过程中整合这些信号的机制尚不完全清楚。在这里，我们显示ERK活性是纤连蛋白刺激的Rho-GTP负载，Rho激酶功能以及散布细胞中黏着斑成熟所必需的。我们确定p190A RhoGAP为粘附组装中ERK信号传导的主要目标，并确定C末端p190A定位和活性中ERK磷酸化的作用。这些观察结果揭示了ERK信号传导在粘附装配中的新作用以及在粘附拆卸中已确立的作用。

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