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首页> 外文期刊>Molecular and Cellular Biology >Spatiotemporal Localization of d-Amino Acid Oxidase and d-Aspartate Oxidases during Development in Caenorhabditis elegans
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Spatiotemporal Localization of d-Amino Acid Oxidase and d-Aspartate Oxidases during Development in Caenorhabditis elegans

机译：秀丽隐杆线虫发育过程中d-氨基酸氧化酶和d-天冬氨酸氧化酶的时空定位

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Recent investigations have shown that a variety of d-amino acids are present in living organisms and that they possibly play important roles in physiological functions in the body. d-Amino acid oxidase (DAO) and d-aspartate oxidase (DDO) are degradative enzymes stereospecific for d-amino acids. They have been identified in various organisms, including mammals and the nematode Caenorhabditis elegans, although the significance of these enzymes and the relevant functions of d-amino acids remain to be elucidated. In this study, we investigated the spatiotemporal localization of C. elegans DAO and DDOs (DDO-1, DDO-2, and DDO-3) and measured the levels of several d- and l-amino acids in wild-type C. elegans and four mutants in which each gene for DAO and the DDOs was partially deleted and thereby inactivated. Furthermore, several phenotypes of these mutant strains were characterized. The results reported in this study indicate that C. elegans DAO and DDOs are involved in egg-laying events and the early development of C. elegans. In particular, DDOs appear to play important roles in the development and maturation of germ cells. This work provides novel and useful insights into the physiological functions of these enzymes and d-amino acids in multicellular organisms.
机译：最近的研究表明，活生物体中存在多种d-氨基酸，它们可能在体内的生理功能中起重要作用。 d-氨基酸氧化酶（DAO）和d-天冬氨酸氧化酶（DDO）是对d-氨基酸具有立体定向的降解酶。尽管这些酶的重要性以及d-氨基酸的相关功能尚待阐明，但已在包括哺乳动物和线虫秀丽隐杆线虫在内的各种生物中鉴定出它们。在这项研究中，我们调查了秀丽隐杆线虫DAO和DDO（DDO-1，DDO-2和DDO-3）的时空定位，并测量了野生秀丽隐杆线虫中几种d和l氨基酸的水平。四个突变体，其中DAO和DDO的每个基因均被部分删除，从而失活。此外，表征了这些突变菌株的几种表型。这项研究报告的结果表明，秀丽隐杆线虫的DAO和DDOs参与了产卵事件和秀丽隐杆线虫的早期发育。特别是，DDO在生殖细胞的发育和成熟中似乎起着重要作用。这项工作为这些酶和d-氨基酸在多细胞生物中的生理功能提供了新颖而有用的见解。

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