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首页> 外文期刊>Molecular and Cellular Biology >NF-κB1 Can Inhibit v-Abl-Induced Lymphoid Transformation by Functioning as a Negative Regulator of Cyclin D1 Expression
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NF-κB1 Can Inhibit v-Abl-Induced Lymphoid Transformation by Functioning as a Negative Regulator of Cyclin D1 Expression

机译：NF-κB1可通过充当细胞周期蛋白D1表达的负调节剂来抑制v-Abl诱导的淋巴样转化

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Mounting evidence implicates deregulated Rel/NF-κB signaling as a common feature of lymphoid malignancies. Despite the fact that they promote the survival and proliferation of normal lymphocytes, the underlying mechanisms by which various Rel/NF-κB proteins with different transcriptional regulatory capacities might facilitate transformation remain to be established. Here we show that the proliferation and tumorigenicity of Abelson murine leukemia virus (A-MuLV)-transformed pre-B cells are enhanced in the absence of NF-κB1 and that this coincides with elevated levels of cyclin D1. Support for a link between cyclin D1 expression and v-Abl transformation came from the finding that proliferation of transformed pre-B cells was reduced in the absence of cyclin D1, while enforced cyclin D1 expression increased the proliferation and tumorigenicity of wild-type transformants. A reduction in endogenous cyclin D1 levels that coincided with NF-κB1 transgene reversal of enhanced nfkb1?/? pre-B-cell transformation, coupled with NF-κB1 inhibition of v-Abl-induced κB-dependent murine cyclin D1 transcription, lends support to a model in which v-Abl-induced cyclin D1 transcription in transformed pre-B cells is controlled by Rel/NF-κB dimers with different activities.
机译：越来越多的证据表明，Rel /NF-κB信号的失调是淋巴系统恶性肿瘤的共同特征。尽管它们促进正常淋巴细胞的存活和增殖，但是具有不同转录调节能力的各种Rel /NF-κB蛋白可能促进转化的潜在机制仍有待建立。在这里，我们显示在缺乏NF-κB1的情况下，Abelson鼠白血病病毒（A-MuLV）转化的pre-B细胞的增殖和致瘤性得到了增强，并且这与细胞周期蛋白D1的升高相吻合。支持细胞周期蛋白D1表达和v-Abl转化之间的联系来自以下发现：在不存在细胞周期蛋白D1的情况下，转化的pre-B细胞的增殖会减少，而强制性细胞周期蛋白D1的表达会增加野生型转化子的增殖和致瘤性。内源性细胞周期蛋白D1水平降低，与增强的 nfkb1 ？/？前B细胞转化的NF-κB1转基因逆转同时发生，同时NF-κB1抑制v -Abl诱导的依赖κB的小鼠 cyclin D1 转录为模型提供了支持，在该模型中，v-Abl诱导的转化的pre-B细胞中的 cyclin D1 转录受以下因素控制Rel /NF-κB二聚体具有不同的活性。

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