• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular and Cellular Biology >A Novel Mechanism for Wnt Activation of Canonical Signaling through the LRP6 Receptor
【24h】

A Novel Mechanism for Wnt Activation of Canonical Signaling through the LRP6 Receptor

机译：通过LRP6受体Wnt激活典型信号的新机制

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

LDL receptor-related protein 6 (LRP6) is a Wnt coreceptor in the canonical signaling pathway, which plays essential roles in embryonic development. We demonstrate here that wild-type LRP6 forms an inactive dimer through interactions mediated by epidermal growth factor repeat regions within the extracellular domain. A truncated LRP6 comprising its transmembrane and cytoplasmic domains is expressed as a constitutively active monomer whose signaling ability is inhibited by forced dimerization. Conversely, Wnts are shown to activate canonical signaling through LRP6 by inducing an intracellular conformational switch which relieves allosteric inhibition imposed on the intracellular domains. Thus, Wnt canonical signaling through LRP6 establishes a novel mechanism for receptor activation which is opposite to the general paradigm of ligand-induced receptor oligomerization.
机译：LDL受体相关蛋白6（LRP6）是经典信号通路中的Wnt受体，在胚胎发育中起着至关重要的作用。我们在这里证明野生型LRP6通过细胞外域内的表皮生长因子重复区域介导的相互作用形成一个无活性的二聚体。包含其跨膜和胞质结构域的截短的LRP6被表示为组成型活性单体，其信号传导能力被强制二聚化抑制。相反地​​，显示出Wnt通过诱导细胞内构象转换来激活通过LRP6的规范信号转导，所述细胞内构象转换减轻了施加于细胞内结构域的变构抑制。因此，通过LRP6的Wnt规范信号传导建立了一种新的受体激活机制，该机制与配体诱导的受体寡聚的一般范式相反。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号