WNT Signaling: an Emerging Mediator of Cancer Cell Metabolism?

Victoria Sherwood

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WNT Signaling: an Emerging Mediator of Cancer Cell Metabolism?

机译：WNT信号：癌细胞代谢的新兴媒介？

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WNT signaling was discovered in tumor models and has been recognized as a regulator of cancer development and progression for over 3 decades. Recent work has highlighted a critical role for WNT signaling in the metabolic homeostasis of mammals, where its misregulation has been heavily implicated in diabetes. While the majority of WNT metabolism research has focused on nontransformed tissues, the role of WNT in cancer metabolism remains underinvestigated. Cancer is also a metabolic disease where oncogenic signaling pathways regulate energy production and macromolecular synthesis to fuel rapidly proliferating tumors. This review highlights the emerging evidence for WNT signaling in the reprogramming of cancer cell metabolism and examines the role of these signaling pathways as mediators of tumor bioenergetics.

机译：WNT信号在肿瘤模型中被发现，并在超过三十年的时间内被认为是癌症发展和进程的调节剂。最近的工作突显了WNT信号在哺乳动物的代谢稳态中的关键作用，其中其失调与糖尿病密切相关。尽管大多数WNT代谢研究集中在未转化的组织上，但WNT在癌症代谢中的作用仍未得到充分研究。癌症也是一种代谢性疾病，致癌信号通路调节能量产生和大分子合成，以促进迅速扩散的肿瘤。这篇综述突出了WNT信号在癌细胞代谢的重新编程中的新兴证据，并研究了这些信号通路作为肿瘤生物能学介质的作用。

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《Molecular and Cellular Biology》 |2015年第1期|共9页
作者
Victoria Sherwood;
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中图分类细胞生物学;
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1. hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression [J] . Michael G. Edwards, Katherine Vandervest, John Arcaroli, Biology Open . 2013,第7期

机译：hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中的抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶点）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用
2. WNT5A-mediated β-catenin-independent signalling is a novel regulator of cancer cell metabolism. [J] . Victoria Sherwood, Shivendra Kumar Chaurasiya, Elin J Ekstr?m, Carcinogenesis . 2014,第4期

机译：WNT5A介导的独立于β-连环蛋白的信号传导是癌细胞代谢的新型调节剂。
3. PFKP Signaling at a Glance: An Emerging Mediator of Cancer Cell Metabolism [J] . Lang Liwei, Chemmalakuzhy Ron, Shay Chloe, Advances in Experimental Medicine and Biology . 2019,第期

机译：PFKP信号通知一目了然：癌细胞代谢的新出现介质
4. An Emerging Cell Kinetics Regulation Network: Integrated Control of Nucleotide Metabolism and Cancer Gene Function [C] . James L. Sherley Symposium on Inosine Monophosphate Dehydrogenase: A Major Therapeutic Target null null . 2000

机译：新兴的细胞动力学调节网络：核苷酸代谢和癌症基因功能的综合控制。
5. Ovarian cancer cells exhibit aberrations in the Wnt signaling pathway, which affect cell proliferation and cadherin expression. [D] . Falcone, Emilia Liana. 2007

机译：卵巢癌细胞在Wnt信号通路中出现畸变，从而影响细胞增殖和钙黏着蛋白表达。
6. WNT Signaling: an Emerging Mediator of Cancer Cell Metabolism? [O] . Victoria Sherwood 2015

机译：WNT信号：癌细胞代谢的新兴媒介？
7. WNT signaling:an emerging mediator of cancer cell metabolism? [O] . Sherwood, Victoria 2015

机译：WNT信号：癌细胞代谢的新兴介质？

WNT Signaling: an Emerging Mediator of Cancer Cell Metabolism?

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