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Context-Dependent Enhancer Selection Confers Alternate Modes of Notch Regulation on argos

机译：上下文相关的增强子选择赋予argos刻槽调节的替代模式

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Wiring between signaling pathways differs according to context, as exemplified by interactions between Notch and epidermal growth factor receptor (EGFR) pathways, which are cooperative in some contexts but antagonistic in others. To investigate mechanisms that underlie different modes of cross talk, we have focused on argos, an EGFR pathway regulator in Drosophila melanogaster which is upregulated by Notch in adult muscle progenitors but is repressed in the wing. Results show that the alternate modes of cross talk depend on the engagement of enhancers with opposite regulatory logic, which are selected by context-determining factors. This is likely to be a general mechanism for enabling the wiring between these pathways to switch according to context.
机译：信号传导途径之间的接线因环境而异，例如Notch和表皮生长因子受体（EGFR）途径之间的相互作用就是例证，这种相互作用在某些情况下是协作的，而在另一些情况下则是拮抗的。为了研究形成不同串扰模式的机制，我们集中研究了果蝇中的EGFR信号通路调节剂 argos ，该信号通路在成年肌肉祖细胞中被Notch上调，但在翼中受到抑制。结果表明，串扰的替代模式取决于具有相反调节逻辑的增强子的参与，该调节逻辑由上下文确定因素选择。这可能是使这些路径之间的连线根据上下文切换的通用机制。

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