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首页> 外文期刊>Molecular and Cellular Biology >Selective Role of a Distinct Tyrosine Residue on Tie2 in Heart Development and Early Hematopoiesis
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Selective Role of a Distinct Tyrosine Residue on Tie2 in Heart Development and Early Hematopoiesis

机译：Tie2不同酪氨酸残基在心脏发育和早期造血中的选择性作用。

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摘要

The development of the cardiovascular system and the development of the early hematopoietic systems are closely related, and both require signaling through the Tie2 receptor tyrosine kinase. Although endothelial cells and hematopoietic cells as well as their precursors share common gene expression patterns during development, it remains completely unknown how Tie2 signaling coordinately regulates cardiovascular development and early hematopoiesis in vivo. We show here that mice with a targeted mutation in tyrosine residue 1100 in the carboxyl-terminal tail of Tie2 display defective cardiac development and impaired hematopoietic and endothelial cell development in the paraaortic splanchnopleural mesoderm similar to that seen in Tie2-null mutant mice. Surprisingly, however, unlike Tie2-null mutant mice, mice deficient in signaling through this tyrosine residue show a normal association of perivascular cells with nascent blood vessels. These studies are the first to demonstrate the physiological importance of a single tyrosine residue in Tie2, and they suggest that multiple tyrosine residues in the receptor may coordinate cardiovascular development and early hematopoietic development.
机译：心血管系统的发育与早期造血系统的发育密切相关，并且都需要通过Tie2受体酪氨酸激酶进行信号传递。尽管内皮细胞和造血细胞及其前体在发育过程中共享共同的基因表达模式，但仍然完全未知Tie2信号如何在体内协调调节心血管发育和早期造血功能。我们在这里显示，在Tie2羧基末端尾巴中的酪氨酸残基1100有针对性突变的小鼠显示出有缺陷的心脏发育以及在腹主动脉胸膜胸膜中胚层中的造血和内皮细胞发育受损，类似于在Tie2空突变小鼠中所见。然而，令人惊讶的是，与Tie2-null突变小鼠不同，缺乏通过该酪氨酸残基发出信号的小鼠表现出血管周围细胞与新生血管的正常关联。这些研究首次证明了Tie2中单个酪氨酸残基的生理重要性，并且表明该受体中的多个酪氨酸残基可以协调心血管的发育和早期造血的发育。

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