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Safeguarding Entry into Mitosis: the Antephase Checkpoint

机译：保护进入有丝分裂：中期检查站

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Maintenance of genomic stability is needed for cells to survive many rounds of division throughout their lifetime. Key to the proper inheritance of intact genome is the tight temporal and spatial coordination of cell cycle events. Moreover, checkpoints are present that function to monitor the proper execution of cell cycle processes. For instance, the DNA damage and spindle assembly checkpoints ensure genomic integrity by delaying cell cycle progression in the presence of DNA or spindle damage, respectively. A checkpoint that has recently been gaining attention is the antephase checkpoint that acts to prevent cells from entering mitosis in response to a range of stress agents. We review here what is known about the pathway that monitors the status of the cells at the brink of entry into mitosis when cells are exposed to insults that threaten the proper inheritance of chromosomes. We highlight issues which are unresolved in terms of our understanding of the antephase checkpoint and provide some perspectives on what lies ahead in the understanding of how the checkpoint functions.
机译：需要维持基因组稳定性，以使细胞在其整个生命周期中能够存活许多轮分裂。完整基因组正确遗传的关键是细胞周期事件在时间和空间上的紧密协调。此外，存在检查点，其作用是监视细胞周期过程的正确执行。例如，DNA损伤和纺锤体组装检查点分别通过在存在DNA或纺锤体损伤的情况下延迟细胞周期进程来确保基因组完整性。最近引起人们关注的一个检查点是前期检查点，该反应点可防止细胞对一系列压力物质的反应进入有丝分裂状态。当细胞暴露于威胁染色体正常遗传的侮辱时，我们在这里回顾了有关监测进入有丝分裂边缘的细胞状态的途径的已知信息。我们重点介绍了我们对前期检查点的理解尚未解决的问题，并就理解检查点如何发挥作用提供了一些观点。

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