Fyn Regulates Adipogenesis by Promoting PIKE-A/STAT5a Interaction

Margaret Chui Ling Tse; Xia Liu; Seran Yang; Keqiang Ye; Chi Bun Chan

首页> 外文期刊>Molecular and Cellular Biology >Fyn Regulates Adipogenesis by Promoting PIKE-A/STAT5a Interaction

【24h】

Fyn Regulates Adipogenesis by Promoting PIKE-A/STAT5a Interaction

机译：Fyn通过促进PIKE-A / STAT5a相互作用来调节脂肪形成。

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Fyn is a tyrosine kinase with multiple roles in a variety of cellular processes. Here we report that Fyn is a new kinase involved in adipocyte differentiation. Elevated Fyn protein is detected specifically in the adipocytes of obese mice. Moreover, Fyn expression increases progressively in 3T3-L1 cells during in vitro adipogenesis, which correlates with its kinase activity. Inhibition of Fyn by either genetic or pharmacological manipulation restrains the 3T3-L1 preadipocytes from fully differentiating into mature adipocytes. Mechanistically, Fyn regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a) through enhancing its interaction with the GTPase phosphoinositide 3-kinase enhancer A (PIKE-A). The STAT5a activity is therefore reduced in Fyn- or PIKE-ablated adipose tissues, leading to diminished expression of adipogenic markers and adipocyte differentiation. Our data thus demonstrate a novel functional interaction between Fyn, PIKE-A, and STAT5a in mediating adipogenesis.

机译：Fyn是一种酪氨酸激酶，在多种细胞过程中具有多种作用。在这里，我们报道Fyn是一种参与脂肪细胞分化的新激酶。在肥胖小鼠的脂肪细胞中特异性检测到升高的Fyn蛋白。此外，在体外成脂过程中3T3-L1细胞中Fyn的表达逐渐增加，这与其激酶活性有关。通过遗传或药理学方法抑制Fyn可以抑制3T3-L1前脂肪细胞完全分化为成熟脂肪细胞。在机制上，Fyn通过增强其与GTPase磷酸肌醇3激酶增强剂A（PIKE-A）的相互作用来调节成脂转录因子信号转导子和转录激活子5a（STAT5a）的活性。因此，在 Fyn -或 PIKE 消融的脂肪组织中STAT5a活性降低，导致脂肪生成标记物的表达减少和脂肪细胞分化。因此，我们的数据证明了Fyn，PIKE-A和STAT5a在介导脂肪形成中的新型功能相互作用。 展开▼

著录项

来源
《Molecular and Cellular Biology》 |2013年第9期|共12页

作者
Margaret Chui Ling Tse; Xia Liu; Seran Yang; Keqiang Ye; Chi Bun Chan;
展开▼

作者单位

展开▼

收录信息

原文格式 PDF

正文语种

中图分类细胞生物学;

关键词

相似文献

外文文献

中文文献

专利

1. Depot- and obesity-related differences in adipogenesisAdipocyte hypertrophy and hyperplasia are known to facilitate lipid storage in adipose tissues by increasing adipocyte cell size and number, respectively. Adipogenesis is the process resulting in adipose tissue hyperplasia. Although depot-specific differences and obesity-related modulation of adipocyte size are well documented, available data on adipogenesis and adipose tissue hyperplasia are less conclusive. Most studies support a reduction of adipogenesis in the obese state. Preadipocytes of the subcutaneous fat depot appear to be more responsive to adipogenic stimulation compared with those from visceral fat compartments in most studies. A number of studies support the notion that adipose tissue expansion through hyperplasia reduces ectopic lipid excess and obesity-related complications. Several genetic variants have been identified in the genes coding for adipogenesis-regulating proteins. While some of these variants have been clearly associated with the phenotypes of obesity and obesity-related alterations, available data highlight the importance of considering gene–gene and gene–diet interactions. [J] . Julie. Lessard, André. Tchernof Clinical lipidology. . 2012,第5期

机译：脂肪形成与肥胖相关的差异已知脂肪细胞肥大和增生分别通过增加脂肪细胞的大小和数量来促进脂质在脂肪组织中的存储。脂肪形成是导致脂肪组织增生的过程。尽管已经有很多文献记载了贮库特异性差异和肥胖相关的脂肪细胞大小调节，但有关脂肪形成和脂肪组织增生的可用数据尚无定论。大多数研究支持在肥胖状态下减少脂肪形成。在大多数研究中，与来自内脏脂肪区室的脂肪细胞相比，皮下脂肪库的前脂肪细胞似乎对脂肪刺激更为敏感。许多研究支持这样的观点，即通过增生的脂肪组织扩张可以减少异位脂质过多和肥胖相关的并发症。在编码脂肪形成调节蛋白的基因中已经鉴定出几种遗传变异。尽管其中一些变异与肥胖症的表型和与肥胖有关的改变明显相关，但现有数据突出了考虑基因-基因和基因-饮食相互作用的重要性。

2. Constitutively active Stat5A and Stat5B promote adipogenesis [J] . Hiroshi Wakao, Rika Wakao, Atsushi Oda, Environmental Health and Preventive Medicine . 2011,第4期

机译：组成性活性Stat5A和Stat5B促进脂肪形成

3. STAT5A expression in Swiss 3T3 cells promotes adipogenesis in vivo in an athymic mice model system. [J] . Stewart WC, Pearcy LA, Floyd ZE, Obesity . 2011,第9期

机译：Swiss 3T3细胞中的STAT5A表达在无胸腺小鼠模型系统中促进体内脂肪形成。

4. The relevance of promoting Self-Regulated Learning and Motivation in a Supercomplex Higher Education Landscape [C] . Isabel Gonçalves, Isabel Sá, Isabel Marrucho International Conference of the Portuguese Society for Engineering Education . 2021

机译：促进超自然的高等教育景观中自治学习和动机的相关性

5. Coordination of cell-cell contact, cell structure, and transcriptional regulation to promote adipogenesis. [D] . Cristancho, Ana Gabriela. 2011

机译：细胞-细胞接触，细胞结构和转录调控的协调以促进脂肪形成。

6. Fyn Regulates Adipogenesis by Promoting PIKE-A/STAT5a Interaction [O] . Margaret Chui Ling Tse, Xia Liu, Seran Yang, 2013

机译：Fyn通过促进PIKE-A / STAT5a相互作用来调节脂肪形成。

7. Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction [O] . Ye, Keqiang, Tse, Margaret Chui Ling, Liu, Xia, 2013

机译：Fyn通过促进pIKE-a / sTaT5a相互作用调节脂肪生成

1. 葡萄糖上调Fyn/Rho相关激酶信号通路促进膀胱肿瘤细胞间隧道纳米管形成 [J] . 陆金金 ,海建斌 ,李凡 . 中华实验外科杂志 . 2018,第009期

2. 固醇调节元件结合蛋白基因的过表达对促进牛胎儿成纤维细胞脂肪形成的影响 [J] . 徐丽 ,郭立平 ,朱淼 . 中国畜牧兽医 . 2013,第005期

3. 基于多肽阵列技术构建穿膜肽靶向抑制Fyn与突触后致密物蛋白95相互作用的实验研究 [J] . 杨秀环 ,马彤彤 ,李舒愉 . 国际麻醉学与复苏杂志 . 2016,第010期

4. 酵母双杂交中Id1与Fyn的相互作用 [J] . 贾思远 ,罗向东 ,齐洁 . 广东医学 . 2004,第010期

5. 生物钟基因Clock通过调节前脂肪细胞增殖抑制脂肪形成的作用及机制研究 [J] . 朱珠 ,袁功盛 ,许利荣 . 中国病理生理杂志 . 2015,第010期

6. 猪Dab1和Fyn基因差异剪接体的克隆及相互作用研究 [C] . 龙欢 ,雷霆 ,袁继红 . 第十六次全国动物遗传育种学术讨论会暨纪念吴仲贤先生诞辰100周年大会 . 2011

7. BMP9通过调节乳腺癌细胞和前体脂肪细胞相互作用抑制乳腺癌的研究 [A] . 张志慧 . 2015

1. 20-羟基蜕皮激素在促进冬虫夏草菌芽生孢子发育形成菌丝中的应用 [P] . 中国专利： CN110106092B . 2021.03.12

2. 20-羟基蜕皮激素在促进冬虫夏草菌芽生孢子发育形成菌丝中的应用 [P] . 中国专利： CN110106092A . 2019-08-09

3. Methods for identifying agents which block the interaction of fyn with PKC-theta, and uses thereof [P] . 外国专利： US5776716A . 1998-07-07

机译：鉴定阻断fyn与PKC-theta相互作用的药物的方法及其用途

4. BIOLOGICAL FUNCTION REGULATING AGENT, EPIDERMAL METABOLISM PROMOTING AGENT, FAT ACCUMULATION INHIBITING AGENT, FAT DECOMPOSITION PROMOTING AGENT, ADIPONECTIN PRODUCTION PROMOTING AGENT, FUNCTIONAL FOOD, COSMETIC, AND METHOD FOR PRODUCING BIOLOGICAL FUNCTION REGULATING AGENT [P] . 外国专利： WO2021205852A1 . 2021-10-14

机译：生物功能调节剂，表皮代谢促进剂，脂肪累积抑制剂，脂肪分解促进剂，脂联素产生促进剂，功能性食品，化妆品和生产生物功能调节剂的方法

5. "Strigolactam derivatives, their uses, plant growth regulating or seed germination promoting composition and methods for regulating plant growth, promoting seed germination, controlling weeds and improving crop plants." [P] . 外国专利： BR112014014916B1 . 2018-11-06

机译：“ Strigolactam衍生物，其用途，调节植物生长或促进种子发芽的成分和调节植物生长，促进种子发芽，控制杂草和改善农作物的方法。”

相关主题

Fyn Regulates Adipogenesis by Promoting PIKE-A/STAT5a Interaction

摘要

著录项

相似文献

相关主题

期刊订阅