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首页> 外文期刊>Molecules >Structure Features and Anti-Gastric Ulcer Effects of Inulin-Type Fructan CP-A from the Roots of Codonopsis pilosula (Franch.) Nannf.
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Structure Features and Anti-Gastric Ulcer Effects of Inulin-Type Fructan CP-A from the Roots of Codonopsis pilosula (Franch.) Nannf.

机译：党参党参的菊粉型果胶CP-A的结构特征和抗胃溃疡作用。

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摘要

Radix Codonopsis has been used in traditional Chinese medicine for strengthening the immune system, improving poor gastrointestinal function, treating gastric ulcers and chronic gastritis and so on. In the present study, an inulin-type fructan CP-A was obtained from the roots of Codonopsis pilosula (Franch.) Nannf. and its structure was confirmed by MS and NMR as (2 → 1) linked-β-d-fructofuranose. The protective effects of CP-A against ethanol-induced acute gastric ulcer in rats were intensively investigated. A Lacy assay demonstrated that CP-A-treated group (50 mg/kg) showed the gastric damage level 1, which was similar to the positive control group, while the model group exhibited the gastric damage level 3. The Guth assay demonstrated that the mucosa ulcer index for CP-A groups at the doses of 50 mg/kg and 25 mg/kg significantly decreased compared with that in the model group (p p < 0.05). The present research reported for the first time that inulin-type fructan CP-A were likely the potential component in Radix Codonopsis for treatment of acute gastric ulcers. View Full-Text
机译：党参已被用于中药，以增强免疫系统，改善胃肠道功能差，治疗胃溃疡和慢性胃炎等。在本研究中，菊粉型果聚糖CP-A从党参党参的根中获得。其结构经MS和NMR证实为（2→1）连接的-β-d-果糖呋喃糖。深入研究了CP-A对乙醇诱导的大鼠急性胃溃疡的保护作用。 Lacy试验表明，CP-A处理组（50 mg / kg）的胃损伤水平为1，与阳性对照组相似，而模型组的胃损伤水平为3。与模型组相比，CP-A组分别在50 mg / kg和25 mg / kg剂量时的黏膜溃疡指数显着降低（pp <0.05）。本研究首次报道菊粉型果聚糖CP-A可能是党参治疗急性胃溃疡的潜在成分。查看全文

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