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首页> 外文期刊>Molecules >Immunomodulatory Effect of Tremella Polysaccharides against Cyclophosphamide-Induced Immunosuppression in Mice
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Immunomodulatory Effect of Tremella Polysaccharides against Cyclophosphamide-Induced Immunosuppression in Mice

机译：银耳多糖对小鼠环磷酰胺诱导的免疫抑制的免疫调节作用。

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Polysaccharides are closely associated with immune regulation, but there are different polysaccharide effects from different sources. In this study, the aim was to investigate the effect of tremella polysaccharides (TP) in cyclophosphamide-induced immunodeficient mice. We observed the thymus and spleen index, liver and spleen pathological changes, and the levels of IL-2, IL-12, INF-γ, TGF-β and Ig G in serum, and we also noted the mRNA expression of IL-1β, IL-4, IL-12 and TGF-β in liver and spleen. Besides, we also measured the best effects of different doses of TP (Low-TP was 20 mg/kg·BW, Middle-TP was 40 mg/kg·BW, and High-TP was 80 mg/kg·BW) on cyclophosphamide-induced immunosuppressed mice. The results were remarkable, and suggested that TP had a significant effect for enhancing immunity in cyclophosphamide-induced immunosuppression, and the immune enhancement of High-TP had the best results in TP-treated mice. It could significantly increase the thymus and spleen index, alleviate pathological features of immunosuppression such as the arrangement of liver sinusoid and hepatic plates was disordered, massive inflammatory cells infiltrated and fatty degeneration of hepatocytes in liver, and red pulp and white pulp were intermixed, splenic corpuscles demolished and disappeared, splenic sinusoid extended, and lymphocytes of spleen were reduced in spleen. Besides, it could also up-regulate serum levels of IL-2, IL-12, INF-γ and Ig G, reduce the level of TGF-β in serum, markedly promote mRNA expression of IL-1β, IL-4 and IL-12 in liver and spleen, and suppress mRNA expression of TGF-β. Above all, TP showed preventive effect for cyclophosphamide-induced immunosuppressed mice.
机译：多糖与免疫调节密切相关，但是来自不同来源的多糖作用却不同。在这项研究中，目的是研究银耳多糖（TP）在环磷酰胺诱导的免疫缺陷小鼠中的作用。我们观察了胸腺和脾脏指数，肝脏和脾脏的病理变化以及血清中IL-2，IL-12，INF-γ，TGF-β和Ig G的水平，还注意到了IL-1β的mRNA表达，肝和脾中的IL-4，IL-12和TGF-β。此外，我们还测量了不同剂量的TP（环磷酰胺为20 mg / kg·BW，中TP为40 mg / kg·BW，High-TP为80 mg / kg·BW）对环磷酰胺的最佳效果。诱导的免疫抑制小鼠。结果是显着的，并且表明TP对增强环磷酰胺诱导的免疫抑制的免疫具有显著作用，而High-TP的免疫增强在TP处理的小鼠中具有最佳效果。可以显着增加胸腺和脾脏指数，减轻免疫抑制的病理特征，如肝窦和肝板排列紊乱，肝内大量炎性细胞浸润和肝细胞脂肪变性，以及红髓和白髓混合，脾脏脾脏细胞消失并消失，脾窦扩展，脾脏淋巴细胞减少。此外，它还可以上调血清中IL-2，IL-12，INF-γ和Ig G的水平，降低血清中TGF-β的水平，明显促进IL-1β，IL-4和IL的mRNA表达。在肝和脾中-12，并抑制TGF-β的mRNA表达。最重要的是，TP对环磷酰胺诱导的免疫抑制小鼠具有预防作用。

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