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Clinical experience with two physiologic bicarbonate|[sol]|lactate peritoneal dialysis solutions in automated peritoneal dialysis

机译:两种生理性碳酸氢盐| [sol] |乳酸盐腹膜透析液在自动腹膜透析中的临床经验

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Clinical experience with two physiologic bicarbonate/lactate peritoneal dialysis solutions in automated peritoneal dialysis. Background. Patients on automated peritoneal dialysis (APD) usually receive larger volumes of dialysis solution and more frequent, shorter exchanges than patients on continuous ambulatory peritoneal dialysis (CAPD), and therefore are likely to derive greater benefit from more physiologic solutions.MethodsPeritoneal dialysis solutions containing 25 mmol/L bicarbonate and either 10 or 15 mmol/L lactate were compared with standard lactate solutions (35 or 40 mmol/L) in two prospective, open-label studies of patients on APD. Each study included a 2-week baseline period (lactate solution), a 6-week treatment period (bicarbonate/lactate solution), and a 2-week follow-up period (same lactate solution as baseline). Biochemical analyses and assessments of vital signs and safety parameters were conducted at baseline, every 2 weeks during treatment, and at the end of the follow-up period. A product use questionnaire was administered in one study at the end of treatment.
机译:在自动腹膜透析中使用两种生理性碳酸氢盐/乳酸盐腹膜透析溶液的临床经验。背景。与连续非卧床腹膜透析(CAPD)的患者相比,进行自动腹膜透析(APD)的患者通常会接受更大体积的透析液和更频繁,更短的更换,因此可能会从更多的生理溶液中获得更大的益处。方法包含25种腹膜透析液在两项针对APD患者的前瞻性开放标签研究中,将mmol / L碳酸氢盐和10或15 mmol / L乳酸盐与标准乳酸盐溶液(35或40 mmol / L)进行了比较。每项研究包括2周的基线期(乳酸盐溶液),6周的治疗期(碳酸氢盐/乳酸盐溶液)和2周的随访期(相同的乳酸盐溶液)。在基线,治疗期间每2周以及随访期结束时进行生化分析和生命体征和安全性参数评估。在治疗结束时,一项研究中使用了产品使用问卷。

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