Creatine supplementation decreases homocysteine in an animal model of uremia

Youri E C Taes; Joris R Delanghe; An S De Vriese; Roeland Rombaut; John Van Camp; Norbert H Lameire

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Creatine supplementation decreases homocysteine in an animal model of uremia

机译：补充肌酸可减少尿毒症动物模型中的同型半胱氨酸

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Creatine supplementation decreases homocysteine in an animal model of uremia.BackgroundHyperhomocysteinemia is prevalent in more than 85% of patients with end-stage renal disease (ESRD) and is thought to contribute to the excess cardiovascular mortality and morbidity. Creatine is synthesized by methylation of guanidinoacetate with formation of S-adenosylhomocysteine and subsequently, homocysteine (Hcy). Creatine supplementation down-regulates its endogenous synthesis and, thus, may reduce Hcy production. The present study investigates the effect of creatine supplementation on Hcy concentrations in an animal model of uremia.

机译：补充肌酸可减少尿毒症动物模型中的同型半胱氨酸。背景高半胱氨酸血症普遍存在于超过85％的终末期肾病（ESRD）患者中，并被认为可导致过多的心血管疾病死亡率和发病率。肌酸是通过胍基乙酸甲酯的甲基化，S-腺苷同型半胱氨酸和随后的高半胱氨酸（Hcy）的合成而合成的。补充肌酸会下调其内源性合成，因此可能会降低Hcy的产生。本研究调查了尿毒症动物模型中补充肌酸对Hcy浓度的影响。

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《Kidney international.》 |2003年第4期|共7页
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Youri E C Taes; Joris R Delanghe; An S De Vriese; Roeland Rombaut; John Van Camp; Norbert H Lameire;
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中图分类泌尿科学（泌尿生殖系疾病）;
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Creatine supplementation decreases homocysteine in an animal model of uremia

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