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首页> 外文期刊>Kidney international. >Superior dialytic clearance of |[beta]|2-microglobulin and p-cresol by high-flux hemodialysis as compared to peritoneal dialysis
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Superior dialytic clearance of |[beta]|2-microglobulin and p-cresol by high-flux hemodialysis as compared to peritoneal dialysis

机译：与腹膜透析相比，高通量血液透析对|β| 2-微球蛋白和对甲酚的透析清除效果更好

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摘要

Both residual renal and dialytic clearance confer to the total solute clearance in dialysis patients. Dialytic clearances of the middle molecule beta-microglobulin (2M) and the protein-bound solute p-cresol (pcr) are generally believed to be higher with peritoneal dialysis (PD) as compared to hemodialysis (HD). Supportive data, however, are lacking. We performed a single-center cross-sectional observational study including 70 unselected patients treated with either high-flux HD (n=20) or PD (n=50). Mid-day serum levels (PD) and time-averaged concentrations (HD) of the water-soluble solutes urea nitrogen, creatinine and phosphate, the middle molecule 2M, and the protein-bound solute pcr were determined. Dialytic solute clearances (l/week/1.73m2) were calculated from total dialysate collection during the mid-week session in HD and 24h dialysate collection in PD. Renal clearances were calculated for each of the respective solutes from a timed urine collection. Total clearances were obtained by summation. HD delivered significantly higher clearances of all retention solutes studied. This superiority was especially pronounced for pcr (30.962.7 vs 4.42.3, HD vs PD, P2M (28.66.6 vs 5.83.1, HD vs PD, P2M, and pcr is achieved by high-flux HD as compared to PD.
机译：残余的肾脏清除率和透析清除率均赋予透析患者总溶质清除率。一般认为，腹膜透析（PD）与血液透析（HD）相比，中分子β-微球蛋白（2M）和结合蛋白的溶质对甲酚（pcr）的透析清除率更高。但是，缺乏支持性数据。我们进行了一项单中心横断面观察性研究，研究对象包括70名未接受过高通量HD（n = 20）或PD（n = 50）治疗的患者。测定了水溶性溶质尿素氮，肌酐和磷酸盐，中间分子2M和结合蛋白的溶质pcr的中值血清水平（PD）和时间平均浓度（HD）。透析溶质清除率（l / week / 1.73m2）由HD的一周中疗程和PD的24h透析液收集的总透析液计算得出。从定时尿液收集中计算出每种溶质的肾脏清除率。总和是通过求和获得的。 HD提供了所有研究的保留质明显更高的清除率。对于pcr（30.962.7 vs 4.42.3，HD vs PD，P2M（28.66.6 vs 5.83.1，HD vs PD，P2M，pcr）而言，这种优势尤其明显。

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